The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation (Q46863341)

25 December 2017

title

The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation (English)

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25 December 2017

author name string

Francis Edwin

1

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25 December 2017

Rakesh Singh

2

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25 December 2017

Raelene Endersby

3

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25 December 2017

Suzanne J Baker

4

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25 December 2017

Tarun B Patel

5

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25 December 2017

language of work or name

English

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publication date

21 December 2005

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25 December 2017

Journal of Biological Chemistry

published in

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25 December 2017

volume

281

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25 December 2017

issue

8

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25 December 2017

page(s)

4816-4822

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25 December 2017

sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways

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1 reference

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Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis

21 January 2018

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Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryo.

21 January 2018

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Inhibition of angiogenesis by a mouse sprouty protein

21 January 2018

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Temporal effects of Sprouty on lung morphogenesis.

21 January 2018

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Expression of sprouty2 during early development of the chick embryo is coincident with known sites of FGF signalling.

21 January 2018

1 reference

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Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells

21 January 2018

1 reference

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The C terminus of sprouty is important for modulation of cellular migration and proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Protein-tyrosine phosphatase-1B (PTP1B) mediates the anti-migratory actions of Sprouty

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Membrane-binding and activation mechanism of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Direct identification of PTEN phosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Regulation of vascular smooth muscle cell proliferation and migration by human sprouty 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Sprouty regulates cell migration by inhibiting the activation of Rac1 GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

The ras/mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, sprouty 1 and sprouty 2 are deregulated in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Sprouty, an intracellular inhibitor of Ras signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Evidence for direct interaction between Sprouty and Cbl

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia

21 January 2018

1 reference

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Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Activation of Rac1 by a Crk SH3-binding protein, DOCK180

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508300200

21 January 2018

Identifiers

DOI

10.1074/JBC.M508300200

1 reference

25 December 2017

PubMed ID

16371366

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25 December 2017