Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1). (Q46798292)

25 December 2017

title

Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1). (English)

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25 December 2017

early-onset autosomal dominant Alzheimer disease

main subject

Alzheimer's disease

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Kentaro Tanemura

1

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25 December 2017

Du-Hua Chui

2

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Tetsuya Fukuda

3

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25 December 2017

Miyuki Murayama

4

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25 December 2017

Jung-Mi Park

5

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25 December 2017

Takumi Akagi

6

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Yoshitaka Tatebayashi

7

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Tomohiro Miyasaka

8

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Tetsuya Kimura

9

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Tsutomu Hashikawa

10

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Yuka Nakano

11

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Takashi Kudo

12

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Masatoshi Takeda

13

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Akihiko Takashima

14

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language of work or name

English

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publication date

23 December 2005

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25 December 2017

Journal of Biological Chemistry

published in

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25 December 2017

volume

281

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page(s)

5037-5041

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issue

8

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25 December 2017

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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Different effects of Alzheimer-associated mutations of presenilin 1 on its processing

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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Protocol for quantitative and qualitative analyses of the in vitro aggregation of synthetic beta-amyloid. A method applicable to the identification of substances that may have therapeutic efficacy for Alzheimer's disease.

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Differential accumulation of soluble amyloid beta peptides 1-40 and 1-42 in human monocytic and neuroblastoma cell lines. Implications for cerebral amyloidogenesis

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Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review

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APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

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A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.

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A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques.

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Familial frontotemporal dementia associated with a novel presenilin-1 mutation

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Alternative transcripts of presenilin-1 associated with frontotemporal dementia

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Frontotemporal dementia and tauopathy

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The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain: evidence for other phenotype-modifying factors.

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Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1 'knock-in' mice.

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Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

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A silver impregnation method for labeling both Alzheimer paired helical filaments and their polypeptides separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.

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Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines

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Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.

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Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

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A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

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Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells.

21 January 2018

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Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

21 January 2018

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Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

21 January 2018

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PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

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Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.

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21 January 2018

Identifiers

DOI

10.1074/JBC.M509145200

1 reference

25 December 2017

PubMed ID

16377636

1 reference

25 December 2017