Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase (Q46593582)

23 December 2017

title

Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase (English)

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23 December 2017

main subject

transmembrane protein

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3

Bart De Strooper

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23 December 2017

Alexandra Tolia

1

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23 December 2017

Katrien Horré

series ordinal

2

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23 December 2017

language of work or name

English

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publication date

15 May 2008

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23 December 2017

Journal of Biological Chemistry

published in

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23 December 2017

volume

283

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23 December 2017

issue

28

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23 December 2017

page(s)

19793-19803

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23 December 2017

Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

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21 January 2018

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21 January 2018

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The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

21 January 2018

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21 January 2018

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Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M802461200

1 reference

23 December 2017

1 reference

23 December 2017