N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2. (Q46448361)

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scientific article published on 22 April 2005

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English	N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2.	scientific article published on 22 April 2005

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2. (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

apoptotic process

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author name string

H Yi

1

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

W Maruyama

2

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

Y Akao

3

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

T Takahashi

4

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

K Iwasa

5

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

M B H Youdim

6

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

M Naoi

7

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

publication date

22 April 2005

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

Journal of Neural Transmission

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

113

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

1

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

21-32

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

https://scigraph.springernature.com/pub.10.1007/s00702-005-0299-z

0 references

Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment

1 reference

https://api.crossref.org/works/10.1007%2FS00702-005-0299-Z

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N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

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A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

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Alkaloids in mammalian tissues. 2. Synthesis of (+)- and (-)-1-substituted-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines

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The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo

1 reference

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Anti-apoptotic function of propargylamine inhibitors of type-B monoamine oxidase

1 reference

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Propiolaldehyde, a pargyline metabolite that irreversibly inhibits aldehyde dehydrogenase. Isolation from a hepatic microsomal system

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Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

1 reference

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Identity of the active site flavin-peptide fragments from the human "A"-form and the bovine "B"-form of monoamine oxidase

1 reference

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Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors

1 reference

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Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members

1 reference

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L-(-)-desmethylselegiline, a metabolite of selegiline [L-(-)-deprenyl], protects mesencephalic dopamine neurons from excitotoxicity in vitro.

1 reference

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Future of neuroprotection in Parkinson's disease

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Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor

1 reference

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12 December 2020

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Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor.

1 reference

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(-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

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1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

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Role of propiolaldehyde and other metabolites in the pargyline inhibition of rat liver aldehyde dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

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Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

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Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

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Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

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Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline

1 reference

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12 December 2020

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A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease

1 reference

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Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

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Effect of structural modification of alkyl N-propargylamines on the selective inhibition of monoamine oxidase B activity

1 reference

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12 December 2020

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Neurochemical and neuroprotective effects of some aliphatic propargylamines: new selective nonamphetamine-like monoamine oxidase B inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

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Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

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Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

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A rapid microfluorimetric determination of monoamine oxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

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An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

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Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022

1 reference

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Targeting programmed cell death in neurodegenerative diseases

1 reference

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The essentiality of Bcl-2, PKC and proteasome–ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline

1 reference

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12 December 2020

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Selegiline's neuroprotective capacity revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

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The anti-Parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells

1 reference

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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12 December 2020

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Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo

1 reference

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Novel (-)deprenyl-derived selective inhibitors of B-type monoamine oxidase. The relation of structure to their action

1 reference

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Bcl-2 family: life-or-death switch

1 reference

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The pharmacology of B-type selective monoamine oxidase inhibitors; milestones in (-)-deprenyl research.

1 reference

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12 December 2020

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Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

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Dopamine-derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00702-005-0299-Z

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843867

ResearchGate publication ID

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