Lys184 deletion in troponin I impairs relaxation kinetics and induces hypercontractility in murine cardiac myofibrils. (Q46445601)

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30 December 2019

title

Lys184 deletion in troponin I impairs relaxation kinetics and induces hypercontractility in murine cardiac myofibrils (English)

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30 December 2019

4

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author name string

Bogdan Iorga

1

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30 December 2019

Natascha Blaudeck

2

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30 December 2019

Johannes Solzin

3

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Ina Stehle

5

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30 December 2019

Alfredo J Lopez Davila

6

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Gabriele Pfitzer

7

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Robert Stehle

8

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publication date

20 December 2007

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30 December 2019

published in

Cardiovascular Research

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volume

77

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issue

4

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page(s)

676-686

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Hypertrophic cardiomyopathy: a systematic review

30 December 2019

cites work

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Parvalbumin corrects slowed relaxation in adult cardiac myocytes expressing hypertrophic cardiomyopathy-linked alpha-tropomyosin mutations.

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Cellular and molecular aspects of familial hypertrophic cardiomyopathy caused by mutations in the cardiac troponin I gene

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Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy

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Familial hypertrophic cardiomyopathy mutations in troponin I (K183D, G203S, K206Q) enhance filament sliding

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Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction-relaxation cycle in isolated cardiac myofibrils

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Force kinetics and individual sarcomere dynamics in cardiac myofibrils after rapid ca(2+) changes

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A dominant role of cardiac molecular motors in the intrinsic regulation of ventricular ejection and relaxation

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Structural basis for Ca2+-regulated muscle relaxation at interaction sites of troponin with actin and tropomyosin

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Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart

21 January 2018

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Kinetic mechanism of the Ca2+-dependent switch-on and switch-off of cardiac troponin in myofibrils

21 January 2018

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Characterization of the cross-bridge force-generating step using inorganic phosphate and BDM in myofibrils from rabbit skeletal muscles

21 January 2018

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Effect of Ca2+ on cross-bridge turnover kinetics in skinned single rabbit psoas fibers: implications for regulation of muscle contraction

21 January 2018

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Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling

21 January 2018

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Ising model of cardiac thin filament activation with nearest-neighbor cooperative interactions

21 January 2018

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Myofilament-generated tension oscillations during partial calcium activation and activation dependence of the sarcomere length-tension relation of skinned cardiac cells

21 January 2018

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Auto-oscillations of skinned myocardium correlating with heartbeat

21 January 2018

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Relaxation kinetics following sudden Ca(2+) reduction in single myofibrils from skeletal muscle

21 January 2018

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Impaired diastolic function after exchange of endogenous troponin I with C-terminal truncated troponin I in human cardiac muscle

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/CVR/CVM113

1 reference

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30 December 2019

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