Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase (Q46440743)

22 December 2017

title

Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase (English)

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22 December 2017

author

Stephen P Jackson

5

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22 December 2017

author name string

Alan Lau

1

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22 December 2017

Karra M Swinbank

2

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22 December 2017

Parvin S Ahmed

3

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22 December 2017

Debra L Taylor

4

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22 December 2017

Graeme C M Smith

6

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22 December 2017

Mark J O'Connor

7

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22 December 2017

publication date

17 April 2005

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22 December 2017

published in

Nature Cell Biology

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22 December 2017

volume

7

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22 December 2017

page(s)

493-500

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issue

5

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22 December 2017

https://scigraph.springernature.com/pub.10.1038/ncb1250

exact match

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cites work

Toward maintaining the genome: DNA damage and replication checkpoints

1 reference

A role for DNA-PK in retroviral DNA integration

21 January 2018

1 reference

Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection

21 January 2018

1 reference

Effect of Ku80 depletion on the preintegrative steps of HIV-1 replication in human cells

21 January 2018

1 reference

Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.

21 January 2018

1 reference

Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response

21 January 2018

1 reference

Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

1 reference

21 January 2018

1 reference

Suppression of retroviral infection by the RAD52 DNA repair protein

21 January 2018

1 reference

Recombinant ATM protein complements the cellular A-T phenotype

21 January 2018

1 reference

The many substrates and functions of ATM

21 January 2018

1 reference

ATM and ATR: networking cellular responses to DNA damage

21 January 2018

1 reference

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

21 January 2018

1 reference

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

1 reference

The ataxia telangiectasia-mutated and Rad3-related protein is dispensable for retroviral integration

21 January 2018

1 reference

DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration

21 January 2018

1 reference

Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine

21 January 2018

1 reference

Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases

21 January 2018

1 reference

Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities

21 January 2018

1 reference

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

1 reference

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

21 January 2018

1 reference

Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair.

21 January 2018

1 reference

Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration

21 January 2018

1 reference

Poly(ADP-ribose) polymerase 1 is not strictly required for infection of murine cells by retroviruses

21 January 2018

1 reference

Processing of an HIV replication intermediate by the human DNA replication enzyme FEN1

21 January 2018

1 reference

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

21 January 2018

1 reference

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT.

21 January 2018

1 reference

A quantitative assay for HIV DNA integration in vivo

21 January 2018

1 reference

Roles of host cell factors in circularization of retroviral dna

21 January 2018

1 reference

7 January 2021

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

1 reference

7 January 2021

Evaluation of synergism or antagonism for the combined action of antiviral agents

1 reference

7 January 2021

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

1 reference

7 January 2021

Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

1 reference

7 January 2021

Drug resistance and drug combination features of the human immunodeficiency virus inhibitor, BCH-10652 [(+/-)-2'-deoxy-3'-oxa-4'-thiocytidine, dOTC].

1 reference

7 January 2021

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

1 reference

7 January 2021

Identifiers

DOI

10.1038/NCB1250

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22 December 2017

Dimensions Publication ID

1033756787

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Fatcat ID

release_aebdzogsybf4tanigffvpru2ua

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/aebdzogsybf4tanigffvpru2ua

24 November 2022

mapped directly with Wikidata item

PubMed ID

15834407

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22 December 2017