Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand. (Q46384476)

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English	Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand.	scientific article

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scholarly article

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15772355

Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand (English)

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12 May 2020

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inferred from title

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based on heuristic

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toxic encephalopathy

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based on heuristic

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Jennifer Pocock

4

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12 May 2020

author name string

Deanna L Taylor

1

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12 May 2020

Fleur Jones

2

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12 May 2020

Eva S F Chen Seho Kubota

3

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12 May 2020

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publication date

1 March 2005

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15772355

Journal of Neuroscience

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12 May 2020

25

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12 May 2020

2952-2964

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12 May 2020

11

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725132&resulttype=core&format=json

12 May 2020

Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia.

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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FasL (CD95L, Apo1L) is expressed in the normal rat and human brain: evidence for the existence of an immunological brain barrier.

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activation.

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Pharmacological agents acting at subtypes of metabotropic glutamate receptors

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https://pubmed.ncbi.nlm.nih.gov/15772355

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Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Fas/CD95/APO-1 can function as a death receptor for neuronal cells in vitro and in vivo and is upregulated following cerebral hypoxic-ischemic injury to the developing rat brain

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Fas ligand-induced apoptosis

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Glutamate as a neurotransmitter in the brain: review of physiology and pathology

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Microglial apoptosis induced by chromogranin A is mediated by mitochondrial depolarisation and the permeability transition but not by cytochrome c release

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Interferon-gamma induces apoptosis and augments the expression of Fas and Fas ligand by microglia in vitro

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Modulation of fas-ligand (Fas-L) on human microglial cells: an in vitro study

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Negative feedback regulation of activated macrophages via Fas-mediated apoptosis

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Mechanisms underlying neuronal death induced by chromogranin A-activated microglia

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Microglial secreted cathepsin B induces neuronal apoptosis.

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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In-vivo measurement of activated microglia in dementia

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Microglia in neurodegeneration: molecular aspects

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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TNF receptor subtype signalling: differences and cellular consequences

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways.

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Peripheral LPS administrations up-regulate Fas and FasL on brain microglial cells: a brain protective or pathogenic event?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide up-regulated in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Microglia as a source and target of cytokines

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Corticotropin-releasing hormone induces proliferation and TNF-alpha release in cultured rat microglia via MAP kinase signalling pathways

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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The signaling adaptors and pathways activated by TNF superfamily

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Tumor necrosis factor: an apoptosis JuNKie?

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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TGF-beta1 represses activation and resultant death of microglia via inhibition of phosphatidylinositol 3-kinase activity

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Microglia release activators of neuronal proliferation mediated by activation of mitogen-activated protein kinase, phosphatidylinositol-3-kinase/Akt and delta-Notch signalling cascades.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Activation of Fas receptor is required for the increased formation of the disialoganglioside GD3 in cultured cerebellar granule cells committed to apoptotic death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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The Fas signalling pathway and its role in the pathogenesis of cancer

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Increased cytotoxic potential of microglia from ALS-transgenic mice

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https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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TNF-alpha in vivo stimulates apoptosis in fibroblasts through caspase-8 activation and modulates the expression of pro-apoptotic genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: role of the glutamate receptor responsive to N-methyl-D-aspartate

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

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Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Expression of the functional soluble form of human fas ligand in activated lymphocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

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The metabotropic glutamate receptors: structure and functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

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Inducible nitric oxide synthase activity of cloned murine microglial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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N-acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

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Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Excitatory amino acids as a final common pathway for neurologic disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

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Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

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Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

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Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of MCCG and MAP4 at the mGluR1b, mGluR2 and mGluR4a human metabotropic glutamate receptor subtypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

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Fas antigen expression in brains of patients with Alzheimer-type dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

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Involvement of the CD95 (APO-1/Fas) receptor/ligand system in multiple sclerosis brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

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Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple sclerosis: Fas signaling in oligodendrocyte cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Activation of phospholipases C and D by the novel metabotropic glutamate receptor agonist tADA

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

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N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

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JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

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Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromogranin A induces a neurotoxic phenotype in brain microglial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-alpha and IFN-gamma render microglia sensitive to Fas ligand-induced apoptosis by induction of Fas expression and down-regulation of Bcl-2 and Bcl-xL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of neurotransmitter release by dihydropyridine-sensitive calcium channels involves tyrosine phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772355

12 December 2020

based on heuristic

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Identifiers

10.1523/JNEUROSCI.4456-04.2005

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725132&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725132&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725132&resulttype=core&format=json

12 May 2020

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