Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats (Q46375080)

21 December 2017

title

Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats (English)

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21 December 2017

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Takanori Hironaka

1

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21 December 2017

Shota Itokawa

2

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21 December 2017

Ken-ichi Ogawara

3

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21 December 2017

Kazutaka Higaki

4

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21 December 2017

Toshikiro Kimura

5

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21 December 2017

publication date

11 September 2008

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21 December 2017

published in

Pharmaceutical Research

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21 December 2017

volume

26

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21 December 2017

issue

1

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21 December 2017

page(s)

40-50

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21 December 2017

Substrate specificity of the di/tripeptide transporter in human intestinal epithelia (Caco-2): identification of substrates that undergo H(+)-coupled absorption

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The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine.

21 January 2018

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Intestinal absorption aspect of non-lipophilic low molecular weight drugs: a case of cephalexin and cefazolin

21 January 2018

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Investigations of influx and accumulation processes of beta-lactam antibiotics and their role in the transmural transfer across rat jejunum

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-008-9703-3

Substrate upregulation of the human small intestinal peptide transporter, hPepT1

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-008-9703-3

Diurnal rhythm of H+-peptide cotransporter in rat small intestine

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-008-9703-3

Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells

21 January 2018

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A pharmacokinetic analysis program (multi) for microcomputer

21 January 2018

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Resistance of proline-containing peptides to ruminal degradation in vitro

21 January 2018

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12 December 2020

Comparative gene expression profiles of intestinal transporters in mice, rats and humans.

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12 December 2020

The surface membrane of the small intestinal epithelial cell. I. Localization of adenyl cyclase

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12 December 2020

Identification of the histidine residues involved in substrate recognition by a rat H+/peptide cotransporter, PEPT1.

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12 December 2020

[Effect of Enterued administration on the intestinal absorption of orally active cefem antibiotics]

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12 December 2020

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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12 December 2020

The diurnal rhythm of the intestinal transporters SGLT1 and PEPT1 is regulated by the feeding conditions in rats.

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12 December 2020

The extracellular pH dependency of transport activity by human oligopeptide transporter 1 (hPEPT1) expressed stably in Chinese hamster ovary (CHO) cells: a reason for the bell-shaped activity versus pH.

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12 December 2020

Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 in vitro cell culture model, and multiple human tissues

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12 December 2020

Functional and molecular expression of intestinal oligopeptide transporter (Pept-1) after a brief fast.

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12 December 2020

Effect of food on absorption of cefadroxil and cephalexin in dogs

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12 December 2020

Absorption behavior of orally administered drugs in rats treated with propantheline

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12 December 2020

Kinetics and mechanism of in vitro uptake of amino-beta-lactam antibiotics by rat small intestine and relation to the intact-peptide transport system

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12 December 2020

Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals

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12 December 2020

Mechanism of dipeptide stimulation of its own transport in a human intestinal cell line

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12 December 2020

Absorption of drugs from the stomach. I. The rat.

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12 December 2020

Carrier-mediated transport of amino-cephalosporins by brush border membrane vesicles isolated from rat kidney cortex

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12 December 2020

Effect of Bile Salts on the Gastrointestinal Absorption of Drugs. II. Mechanism of the Enhancement of the Intestinal Absorption of Sulfaguanidine by Bile Salts

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12 December 2020

Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds.

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12 December 2020

Physiological parameters in laboratory animals and humans

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12 December 2020

Hormonal regulation of oligopeptide transporter pept-1 in a human intestinal cell line

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12 December 2020

Decisive structural determinants for the interaction of proline derivatives with the intestinal H+/peptide symporter

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12 December 2020

Prediction of oral absorption of griseofulvin, a BCS class II drug, based on GITA model: utilization of a more suitable medium for in-vitro dissolution study

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12 December 2020

Peptide transporter in the rat small intestine: ultrastructural localization and the effect of starvation and administration of amino acids

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12 December 2020

Regulation of drug transporters by PDZ adaptor proteins and nuclear receptors

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12 December 2020

Regional expression and dietary regulation of rat small intestinal peptide and amino acid transporter mRNAs

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12 December 2020

Time-dependent oral absorption models

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12 December 2020

Analysis and prediction of absorption behavior of colon-targeted prodrug in rats by GI-transit-absorption model

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12 December 2020

Carrier-mediated uptake of cephalexin in human intestinal cells

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12 December 2020

Expression profiles of various transporters for oligopeptides, amino acids and organic ions along the human digestive tract

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12 December 2020

A modified procedure for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes. Their use in investigating some properties of d-glucose and choline transport systems

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12 December 2020

The use of liposomes as a model for drug absorption: β-lactam antibiotics

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12 December 2020

Contribution of passive transport mechanisms to the intestinal absorption of beta-lactam antibiotics

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12 December 2020

Up-regulation of P-glycoprotein expression in small intestine under chronic serotonin-depleted conditions in rats

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12 December 2020

Analysis and prediction of absorption profile including hepatic first-pass metabolism of N-methyltyramine, a potent stimulant of gastrin release present in beer, after oral ingestion in rats by gastrointestinal-transit-absorption model.

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12 December 2020

Symmetry of H+ binding to the intra- and extracellular side of the H+-coupled oligopeptide cotransporter PepT1.

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12 December 2020

Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten

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12 December 2020

Saturable absorption of amino-cephalosporins by the rat intestine

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12 December 2020

PepT1 mRNA expression is induced by starvation and its level correlates with absorptive transport of cefadroxil longitudinally in the rat intestine

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12 December 2020

Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux

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12 December 2020

Prediction of plasma concentration-time curve of orally administered theophylline based on a scintigraphic monitoring of gastrointestinal transit in human volunteers

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12 December 2020

Characterization of the oral absorption of beta-lactam antibiotics. I. Cephalosporins: determination of intrinsic membrane absorption parameters in the rat intestine in situ.

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12 December 2020

Prediction of the plasma concentration profiles of orally administered drugs in rats on the basis of gastrointestinal transit kinetics and absorbability

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12 December 2020

Gastrointestinal transit and drug absorption

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12 December 2020

A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 1: system characterisation.

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12 December 2020

Intestinal peptide transport systems and oral drug availability

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12 December 2020

Characterization of stably transfected kidney epithelial cell line expressing rat H+/peptide cotransporter PEPT1: localization of PEPT1 and transport of beta-lactam antibiotics.

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12 December 2020

N-terminal halves of rat H+/peptide transporters are responsible for their substrate recognition

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12 December 2020

Cephalexin preparation with prolonged activity (author's transl)

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12 December 2020

Carrier-mediated intestinal transport of drugs

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12 December 2020

Peptide transporters in the intestine and the kidney

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12 December 2020

alpha(2)-adrenergic receptors stimulate oligopeptide transport in a human intestinal cell line

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12 December 2020

Correlation between epithelial cell permeability of cephalexin and expression of intestinal oligopeptide transporter

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12 December 2020

10.1007/S11095-008-9703-3

Identifiers

DOI

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21 December 2017

PubMed ID

18784906

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21 December 2017