Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation (Q46355550)

21 December 2017

title

Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation (English)

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21 December 2017

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1

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21 December 2017

Frank Beier

series ordinal

4

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21 December 2017

author name string

Shirine E Usmani

series ordinal

2

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21 December 2017

John S Mort

series ordinal

3

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21 December 2017

publication date

12 October 2009

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21 December 2017

published in

Laboratory Investigation

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21 December 2017

volume

90

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21 December 2017

page(s)

20-30

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21 December 2017

issue

1

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21 December 2017

https://scigraph.springernature.com/pub.10.1038/labinvest.2009.111

exact match

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cites work

Understanding NSAIDs: from aspirin to COX-2

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Prospects for disease modification in osteoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Structure-function relationships for the EGF/TGF-alpha family of mitogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

The MEK-ERK Signaling Pathway Is a Negative Regulator of Cartilage-specific Gene Expression in Embryonic Limb Mesenchyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Aggrecan degradation in human intervertebral disc and articular cartilage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Requirement for RAR-mediated gene repression in skeletal progenitor differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Induction of chondrogenesis in limb mesenchymal cultures by disruption of the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Osteoarthritis cartilage histopathology: grading and staging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Role of small GTPase Rho in regulating corneal epithelial wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Dephosphorylation of cofilin is regulated through Ras and requires the combined activities of the Ras-effectors MEK and PI3K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Molecular mechanism of cofilin dephosphorylation by ouabain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes

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1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

21 January 2018

1 reference

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Global analyses of gene expression in early experimental osteoarthritis

1 reference

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Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis

1 reference

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Sustained and distinctive patterns of gene activation in synovial fibroblasts and whole synovial tissue obtained from inflammatory synovitis

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IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways

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TNFα suppresses link protein and type II collagen expression in chondrocytes: Role of MEK1/2 and NF‐κB signaling pathways

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Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels

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Epidermal growth factor negatively regulates chondrogenesis of mesenchymal cells by modulating the protein kinase C-alpha, Erk-1, and p38 MAPK signaling pathways

1 reference

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Identifiers

DOI

1 reference

21 December 2017

PubMed ID

19823173

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21 December 2017