A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle. (Q46346112)

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scientific article published on 25 September 2008

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English	A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle.	scientific article published on 25 September 2008

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scholarly article

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14 January 2020

A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle (English)

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14 January 2020

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Paul L. Greenhaff

5

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14 January 2020

Dumitru Constantin-Teodosiu

2

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14 January 2020

author name string

Hannah Crossland

1

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14 January 2020

Sheila M Gardiner

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14 January 2020

Despina Constantin

4

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25 September 2008

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14 January 2020

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12

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Journal of Physiology

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14 January 2020

586

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14 January 2020

5589-5600

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14 January 2020

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14 January 2020

Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice.

1 reference

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The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy

1 reference

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Temporal changes in the involvement of pyruvate dehydrogenase complex in muscle lactate accumulation during lipopolysaccharide infusion in rats.

1 reference

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The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle

1 reference

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26 August 2018

Regulation of muscle protein synthesis during sepsis and inflammation

1 reference

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Inactivity and inflammation in the critically ill patient

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Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states

1 reference

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Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling

1 reference

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Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation

1 reference

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26 August 2018

Skeletal muscle hypertrophy and atrophy signaling pathways

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26 August 2018

Tumor necrosis factor-{alpha} decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt.

1 reference

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26 August 2018

Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase

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IKKbeta/NF-kappaB activation causes severe muscle wasting in mice

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26 August 2018

Balancing muscle hypertrophy and atrophy.

1 reference

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26 August 2018

The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655379

26 August 2018

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2655379

26 August 2018

Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors

1 reference

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Stress-hyperglycemia, insulin and immunomodulation in sepsis

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26 August 2018

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

1 reference

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26 August 2018

Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation

1 reference

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26 August 2018

Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal muscle after LPS injection

1 reference

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26 August 2018

The immunopathogenesis of sepsis

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26 August 2018

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

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26 August 2018

Identification of ubiquitin ligases required for skeletal muscle atrophy

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26 August 2018

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

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Muscle cachexia: current concepts of intracellular mechanisms and molecular regulation

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Extraction of nuclear proteins from striated muscle tissue.

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Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation

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26 August 2018

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

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26 August 2018

Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles

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26 August 2018

Sepsis-induced alterations in pyruvate dehydrogenase complex activity in rat skeletal muscle: effects on plasma lactate

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26 August 2018

Increased mRNA levels for components of the lysosomal, Ca2+-activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients.

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26 August 2018

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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

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26 August 2018

Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids

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26 August 2018

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1 reference

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26 August 2018

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26 August 2018

Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18818241

12 December 2020

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Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/18818241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18818241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain activation causes a proteasome-dependent increase in protein degradation and inhibits the Akt signalling pathway in rat diaphragm muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18818241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18818241

12 December 2020

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inferred from PubMed ID database lookup

Muscle fibre atrophy in critically ill patients is associated with the loss of myosin filaments and the presence of lysosomal enzymes and ubiquitin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18818241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of the ubiquitin-proteasome pathway to overall muscle proteolysis in hypercatabolic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18818241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin sensitivity of glucose and fat metabolism in severe sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18818241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A descriptive study of skeletal muscle metabolism in critically ill patients: free amino acids, energy-rich phosphates, protein, nucleic acids, fat, water, and electrolytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18818241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular regulation of protein degradation during sepsis is different in fast- and slow-twitch muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18818241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle composition in relation to age and sex

1 reference

https://pubmed.ncbi.nlm.nih.gov/18818241

12 December 2020

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inferred from PubMed ID database lookup

A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue

1 reference

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Identifiers

10.1113/JPHYSIOL.2008.160150

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14 January 2020

0 references

1 reference

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14 January 2020

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