ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage? (Q46297052)

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English	ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage?	scientific article

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scholarly article

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28968864

ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage? (English)

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28968864

3

object named as

Ulla Stenius

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Europe PubMed Central

21 December 2017

2

object named as

Johan Högberg

1 reference

Europe PubMed Central

21 December 2017

author name string

Huiyuan Zheng

1

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28968864

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publication date

15 September 2017

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28968864

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28968864

38

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28968864

1196-1206

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28968864

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28968864

Insights into autotaxin: how to produce and present a lipid mediator.

1 reference

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Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis

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Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells

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Lysophosphatidic acid and autotaxin: emerging roles in innate and adaptive immunity.

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Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: a focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays.

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Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.

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Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression

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Toluene diisocyanate: Induction of the autotaxin-lysophosphatidic acid axis and its association with airways symptoms

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Lung pathology in U.S. coal workers with rapidly progressive pneumoconiosis implicates silica and silicates

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The carcinogenic action of crystalline silica: a review of the evidence supporting secondary inflammation-driven genotoxicity as a principal mechanism

1 reference

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Silica-induced inflammasome activation in macrophages: role of ATP and P2X7 receptor.

1 reference

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Silica induces NLRP3 inflammasome activation in human lung epithelial cells

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ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

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The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells

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CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells

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Size-dependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release

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Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells

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Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor

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Statins inhibit Akt/PKB signaling via P2X7 receptor in pancreatic cancer cells

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Surface modification of quartz inhibits toxicity, particle uptake, and oxidative DNA damage in human lung epithelial cells.

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NLRPs, microbiota, and gut homeostasis: unravelling the connection.

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21 January 2018

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGX100

21 January 2018

DNA double-strand breaks activate ATM independent of mitochondrial dysfunction in A549 cells

1 reference

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C4b-binding protein: The good, the bad and the deadly. Novel functions of an old friend

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Lysophosphatidic acid-induced membrane ruffling and brain-derived neurotrophic factor gene expression are mediated by ATP release in primary microglia.

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21 January 2018

ATM regulates NF-κB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment

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21 January 2018

Autotaxin expression and its connection with the TNF-alpha-NF-kappaB axis in human hepatocellular carcinoma.

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The P2X7 receptor: a key player in IL-1 processing and release

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Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection.

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DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function

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Autotaxin and Endotoxin-Induced Acute Lung Injury

1 reference

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Hepatocyte autotaxin expression promotes liver fibrosis and cancer.

1 reference

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Autotaxin emerges as a therapeutic target for idiopathic pulmonary fibrosis: limiting fibrosis by limiting lysophosphatidic acid synthesis

1 reference

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Development of lysophosphatidic acid pathway modulators as therapies for fibrosis

1 reference

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Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein structure.

1 reference

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Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis

1 reference

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Molecular mechanisms in progressive idiopathic pulmonary fibrosis

1 reference

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Silica exposure among male current smokers is associated with a high risk of developing ACPA-positive rheumatoid arthritis.

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Prospective risk of rheumatologic disease associated with occupational exposure in a cohort of male construction workers

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NBS1 is required for macrophage homeostasis and functional activity in mice

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The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where.

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Is silicosis required for silica-associated lung cancer?

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One agent, many diseases: exposure-response data and comparative risks of different outcomes following silica exposure

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DNA released from dying host cells mediates aluminum adjuvant activity

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Identifiers

10.1093/CARCIN/BGX100

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28968864

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/28968864

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