Further characterization of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in C57BL/6 mice: role of 5-HT(2A) serotonergic and alpha (1) adrenergic antagonism (Q46260468)

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English	Further characterization of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in C57BL/6 mice: role of 5-HT(2A) serotonergic and alpha (1) adrenergic antagonism	scientific article

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scholarly article

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989659

Further characterization of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in C57BL/6 mice: role of 5-HT(2A) serotonergic and alpha (1) adrenergic antagonism (English)

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989659

author name string

Scott D Philibin

1

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989659

D Matthew Walentiny

2

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989659

Sarah A Vunck

3

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989659

Adam J Prus

4

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989659

Herbert Y Meltzer

5

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989659

Joseph H Porter

6

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989659

publication date

7 November 2008

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989659

number of pages

13

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Psychopharmacology

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989659

203

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20 December 2017

http://europepmc.org/abstract/MED/18989659

2

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Europe PubMed Central

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http://europepmc.org/abstract/MED/18989659

303-315

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989659

https://scigraph.springernature.com/pub.10.1007/s00213-008-1385-3

0 references

Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase

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https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

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PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties.

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https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

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Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

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https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

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Towards a muscarinic hypothesis of schizophrenia.

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https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

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Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice

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https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

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D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs

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https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

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Generalization to atypical antipsychotic drugs depends on training dose in rats trained to discriminate 1.25 mg/kg clozapine versus 5.0 mg/kg clozapine versus vehicle in a three-choice drug discrimination task.

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https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

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Antagonism by neuroleptics of serotonin 5-HT1A and 5-HT2 receptors of normal human brain in vitro

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https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

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A comparison of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in DBA/2 and C57BL/6 inbred mice

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https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

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Differential effects of fluoxetine and citalopram treatments on serotonin 5-HT(2C) receptor occupancy in rat brain.

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https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

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The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent

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https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

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The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

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Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat.

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https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

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Comparative characterisation of the discriminative stimulus properties of clozapine and other antipsychotics in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

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Serotonergic drugs do not substitute for clozapine in clozapine-trained rats in a two-lever drug discrimination procedure

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

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Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D(2L) receptors are modified by co-transfection of D(3) receptors: potential role of heterodimer formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

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Phenothiazine drug metabolites: dopamine D2 receptor, alpha 1- and alpha 2-adrenoceptor binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-Yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: I. Receptorial and neurochemical profile in compar

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

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Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discriminative stimulus properties of the atypical neuroleptic clozapine in rats: tests with subtype selective receptor ligands.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S-16924, a novel, potential antipsychotic with marked serotonin1A agonist properties. IV. A drug discrimination comparison with clozapine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generalization of clozapine as compared to other antipsychotic agents to a discriminative stimulus elicited by the serotonin (5-HT)2A antagonist, MDL100,907.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discriminative-stimulus effects of clozapine in squirrel monkeys: comparison with conventional and novel antipsychotic drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of muscarinic cholinergic receptors in the discriminative stimulus properties of clozapine in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aripiprazole (OPC-14597) fully substitutes for the 5-HT1A receptor agonist LY293284 in the drug discrimination assay in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interspecies variability and drug interactions of clozapine metabolism by microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

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Behavioral phenotyping of rodents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JL13, a pyridobenzoxazepine compound with potential atypical antipsychotic activity: a review of its behavioural properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulus properties of the "atypical" antipsychotic zotepine in rats: comparisons with clozapine and quetiapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discriminative stimulus properties of the atypical antipsychotic drug clozapine in rats trained to discriminate 1.25 mg/kg clozapine vs. 5.0 mg/kg clozapine vs. vehicle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissecting the behaviour of transgenic mice: is it the mutation, the genetic background, or the environment?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonin receptor mechanisms mediate the discriminative stimulus properties of the atypical antipsychotic clozapine in C57BL/6 mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of N-desmethylclozapine as a potential antipsychotic--preclinical studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology of N-desmethylclozapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic mediation of the discriminative stimulus properties of clozapine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: II. Functional profile and a mul

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: II. Functional profile in comparison to clozapine a

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the novel antipsychotic agent 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro -2(1H)-quinolinone (OPC-14597) on prolactin release from the rat anterior pituitary gland

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clozapine discrimination with a low training dose distinguishes atypical from typical antipsychotic drugs in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further investigations of the interactions of antipsychotics with the (-)2,5-dimethoxy-4-methylamphetamine (DOM) discriminative stimulus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discriminative stimulus properties of clozapine and chlorpromazine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of olanzapine substitution in rats discriminating clozapine by the D2/3 agonist quinpirole.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discriminative stimulus properties of S32504, a novel D3/D2 receptor agonist and antiparkinson agent, in rats: attenuation by the antipsychotics, aripiprazole, bifeprunox, N-desmethylclozapine, and by selective antagonists at dopamine D2 but not D3

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inter-animal olfactory cues in operant drug discrimination procedures in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-008-1385-3

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989659

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989659

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