Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver (Q46260461)

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English	Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver	scientific article

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scholarly article

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver (English)

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

Oddrun Gudbrandsen

7

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20 December 2017

http://europepmc.org/abstract/MED/18989661

2

object named as

Audun O Vik-Mo

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20 December 2017

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object named as

Vidar M Steen

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20 December 2017

http://europepmc.org/abstract/MED/18989661

5

object named as

Kjetil Berge

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

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object named as

Sverre Mørk

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

author name string

Johan Fernø

1

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20 December 2017

http://europepmc.org/abstract/MED/18989661

Goran Jassim

3

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20 December 2017

http://europepmc.org/abstract/MED/18989661

Bjarte Håvik

4

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http://europepmc.org/abstract/MED/18989661

Silje Skrede

6

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http://europepmc.org/abstract/MED/18989661

Jo Waage

8

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20 December 2017

http://europepmc.org/abstract/MED/18989661

Niclas Lunder

9

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20 December 2017

http://europepmc.org/abstract/MED/18989661

Rolf K Berge

11

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20 December 2017

http://europepmc.org/abstract/MED/18989661

Hugo A Jørgensen

12

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20 December 2017

http://europepmc.org/abstract/MED/18989661

publication date

30 October 2008

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20 December 2017

http://europepmc.org/abstract/MED/18989661

number of pages

12

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Psychopharmacology

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http://europepmc.org/abstract/MED/18989661

203

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http://europepmc.org/abstract/MED/18989661

1

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http://europepmc.org/abstract/MED/18989661

73-84

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20 December 2017

http://europepmc.org/abstract/MED/18989661

https://scigraph.springernature.com/pub.10.1007/s00213-008-1370-x

0 references

SREBP-1c transcription factor and lipid homeostasis: clinical perspective

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1370-X

21 January 2018

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1370-X

21 January 2018

Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1370-X

21 January 2018

Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1370-X

21 January 2018

Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein in the regulation of adipogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

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inferred from PubMed ID database lookup

Diminished suicidal and aggressive behavior, high plasma norepinephrine levels, and serum triglyceride levels in chronic neuroleptic-resistant schizophrenic patients maintained on clozapine.

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https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

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Elevated serum triglycerides with clozapine resolved with risperidone in four patients

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https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

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A new transgenic rat model of hepatic steatosis and the metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of clozapine and risperidone: a review of recent literature

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Olanzapine induces SREBP-1-related adipogenesis in 3T3-L1 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Alterations of lipid metabolism and gene expression in rat adipocytes during chronic olanzapine treatment

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https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

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The 5-HT2C receptor and antipsychoticinduced weight gain - mechanisms and genetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

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Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

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SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinoid x receptor heterodimers in the metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Lipid accumulation in the livers of chlorpromazine-treated rats does not induce peroxisome proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Clozapine-associated elevation in serum triglycerides

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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A model for antipsychotic-induced obesity in the male rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

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"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Prevalence of the metabolic syndrome among patients receiving clozapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

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Fatty acid regulation of hepatic gene transcription.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of L

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clozapine-induced agranulocytosis. Incidence and risk factors in the United States

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

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H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Chronic treatment with antipsychotics in rats as a model for antipsychotic-induced weight gain in human

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of lipid biosynthesis genes in peripheral blood cells of olanzapine-treated patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Metabolomic mapping of atypical antipsychotic effects in schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

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Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: A five-year naturalistic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

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From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Metabolic syndrome X: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Clozapine: weight gain in a pair of monozygotic twins concordant for schizophrenia and mild mental retardation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Tissue concentrations of clozapine and its metabolites in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

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The AGNP-TDM expert group consensus guidelines: therapeutic drug monitoring in psychiatry

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Antipsychotic-induced weight gain: a comprehensive research synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clozapine and weight gain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum triglyceride levels in patients treated with clozapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The emerging role of glutamate in the pathophysiology and treatment of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Acyl-coenzyme A:cholesterol acyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

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Treatment-resistant schizophrenic patients respond to clozapine after olanzapine non-response.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18989661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-008-1370-X

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/18989661

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