The mitochondrial UPR: mechanisms, physiological functions and implications in ageing (Q46256193)

20 December 2017

title

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing (English)

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20 December 2017

author name string

Tomer Shpilka

series ordinal

1

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20 December 2017

Cole M Haynes

series ordinal

2

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20 December 2017

publication date

22 November 2017

1 reference

20 December 2017

Nature Reviews Molecular Cell Biology

published in

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20 December 2017

https://scigraph.springernature.com/pub.10.1038/nrm.2017.110

exact match

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The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans

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Mitonuclear protein imbalance as a conserved longevity mechanism

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Caenorhabditis elegans pathways that surveil and defend mitochondria

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Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.

21 January 2018

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Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

21 January 2018

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A mitochondrial specific stress response in mammalian cells

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Fusion and fission: interlinked processes critical for mitochondrial health

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ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

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Metabolism and the UPR(mt).

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Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

21 January 2018

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Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans

21 January 2018

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Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

21 January 2018

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Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

21 January 2018

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Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR(mt).

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Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis.

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Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response

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Rates of behavior and aging specified by mitochondrial function during development

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Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans

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The unfolded protein response: from stress pathway to homeostatic regulation

21 January 2018

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ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans

21 January 2018

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Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

21 January 2018

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Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response

21 January 2018

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Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

21 January 2018

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The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway

21 January 2018

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Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling

21 January 2018

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The protein import machinery of mitochondria-a regulatory hub in metabolism, stress, and disease

21 January 2018

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Oxidative stress inhibits the mitochondrial import of preproteins and leads to their degradation

21 January 2018

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Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

21 January 2018

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The protein import motor of mitochondria

21 January 2018

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Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2

21 January 2018

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YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation

21 January 2018

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Emerging roles of mitochondrial proteases in neurodegeneration

21 January 2018

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Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart

21 January 2018

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Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

The integrated stress response.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease

21 January 2018

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

21 January 2018

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Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Discovery of genes activated by the mitochondrial unfolded protein response (mtUPR) and cognate promoter elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

The chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2α phosphorylation in virus infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Mitochondrial protein quality control by the proteasome involves ubiquitination and the protease Omi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Sex specific activation of the ERα axis of the mitochondrial UPR (UPRmt) in the G93A-SOD1 mouse model of familial ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

The role of histone demethylases in cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

21 January 2018

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FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases

21 January 2018

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21 January 2018

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FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders

21 January 2018

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FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study.

21 January 2018

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Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

21 January 2018

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DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans

21 January 2018

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Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).

21 January 2018

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Joint mouse-human phenome-wide association to test gene function and disease risk

21 January 2018

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dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective

21 January 2018

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Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response.

21 January 2018

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Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response.

21 January 2018

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The pharmacological regulation of cellular mitophagy.

21 January 2018

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

21 January 2018

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Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

21 January 2018

1 reference

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21 January 2018

Mechanisms of mitophagy

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans

21 January 2018

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Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans

21 January 2018

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A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Determination of life-span in Caenorhabditis elegans by four clock genes

21 January 2018

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Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Muscle mitohormesis promotes longevity via systemic repression of insulin signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging

21 January 2018

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The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans

21 January 2018

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Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

21 January 2018

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The paradox of mitochondrial dysfunction and extended longevity

21 January 2018

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The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

TOR signaling couples oxygen sensing to lifespan in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity

21 January 2018

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21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Evidence for Mitochondrial UPR Gene Activation in Familial and Sporadic Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Potential involvement of the mitochondrial unfolded protein response in depressive-like symptoms in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

21 January 2018

Targeting ATF5 in Cancer

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres.

21 January 2018

1 reference

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Co-opting the unfolded protein response to elicit olfactory receptor feedback

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Mitochondria in innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Causes, consequences, and reversal of immune system aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Interactions between bacterial pathogens and mitochondrial cell death pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Mitochondrial DNA in innate immune responses and inflammatory pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Targeting of Helicobacter pylori VacA to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Volatile metabolites of pathogens: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

High direct estimate of the mutation rate in the mitochondrial genome of Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Universal heteroplasmy of human mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Mammalian Mitochondria and Aging: An Update

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Stable heteroplasmy but differential inheritance of a large mitochondrial DNA deletion in nematodes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.110

Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Stress-regulated translational attenuation adapts mitochondrial protein import through Tim17A degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

The origin and early evolution of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Mitochondrial diseases: the contribution of organelle stress responses to pathology.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Selective induction of mitochondrial chaperones in response to loss of the mitochondrial genome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.110

Respiratory chain of antimycin A-producing Streptomyces antibioticus

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29165426

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29165426

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Oligomycin, a new antifungal antibiotic

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29165426

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM.2017.110

1 reference

20 December 2017

PubMed ID

29165426

1 reference

20 December 2017