Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. (Q46202457)

20 December 2017

title

Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. (English)

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20 December 2017

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Hae Yong Yoo

1

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20 December 2017

Akiko Kumagai

2

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20 December 2017

Anna Shevchenko

3

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20 December 2017

Andrej Shevchenko

4

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20 December 2017

William G Dunphy

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20 December 2017

language of work or name

English

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publication date

19 April 2007

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20 December 2017

Journal of Biological Chemistry

published in

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20 December 2017

volume

282

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20 December 2017

page(s)

17501-17506

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20 December 2017

issue

24

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20 December 2017

Cell cycle checkpoint signaling through the ATM and ATR kinases

cites work

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

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Rapid activation of ATR by ionizing radiation requires ATM and Mre11

21 January 2018

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ATM regulates ATR chromatin loading in response to DNA double-strand breaks

21 January 2018

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TopBP1 activates the ATR-ATRIP complex

21 January 2018

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Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase

21 January 2018

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Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures

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Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses

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Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.

21 January 2018

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Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin

21 January 2018

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The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.

21 January 2018

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Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling.

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A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival

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21 January 2018

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Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.

21 January 2018

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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

21 January 2018

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21 January 2018

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An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M701770200

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20 December 2017

PubMed ID

17446169

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20 December 2017