Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. (Q46202457)

20 December 2017

title

Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. (English)

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20 December 2017

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4

Andrej Shevchenko

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20 December 2017

Anna Shevchenko

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object named as

Anna Shevchenko

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20 December 2017

William G Dunphy

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object named as

William G Dunphy

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20 December 2017

author name string

Hae Yong Yoo

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20 December 2017

Akiko Kumagai

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20 December 2017

publication date

19 April 2007

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20 December 2017

Journal of Biological Chemistry

language of work or name

English

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published in

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20 December 2017

volume

282

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20 December 2017

issue

24

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20 December 2017

page(s)

17501-17506

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20 December 2017

Cell cycle checkpoint signaling through the ATM and ATR kinases

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Rapid activation of ATR by ionizing radiation requires ATM and Mre11

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ATM regulates ATR chromatin loading in response to DNA double-strand breaks

21 January 2018

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TopBP1 activates the ATR-ATRIP complex

21 January 2018

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Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase

21 January 2018

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Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

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Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures

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Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses

21 January 2018

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Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.

21 January 2018

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Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

21 January 2018

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Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin

21 January 2018

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The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.

21 January 2018

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Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling.

21 January 2018

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A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival

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The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint

21 January 2018

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Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.

21 January 2018

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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

21 January 2018

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21 January 2018

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An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M701770200

1 reference

20 December 2017

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20 December 2017