Hoxa9 collaborates with E2A-PBX1 in mouse B cell leukemia in association with Flt3 activation and decrease of B cell gene expression (Q46178511)

20 December 2017

title

Hoxa9 collaborates with E2A-PBX1 in mouse B cell leukemia in association with Flt3 activation and decrease of B cell gene expression (English)

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20 December 2017

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20 December 2017

Daniel Sinnett

object named as

Daniel Sinnett

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author name string

Mona Hassawi

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20 December 2017

Elena A Shestakova

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20 December 2017

Marilaine Fournier

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20 December 2017

Charles-Étienne Lebert-Ghali

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20 December 2017

Gratianne Vaisson

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20 December 2017

Héloïse Frison

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20 December 2017

Ramon Vidal

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20 December 2017

Janet J Bijl

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20 December 2017

publication date

7 October 2013

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20 December 2017

published in

Developmental Dynamics

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20 December 2017

volume

243

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20 December 2017

issue

1

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20 December 2017

page(s)

145-158

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20 December 2017

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

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A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL

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Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

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Heterodimerization of Hox proteins with Pbx1 and oncoprotein E2a-Pbx1 generates unique DNA-binding specifities at nucleotides predicted to contact the N-terminal arm of the Hox homeodomain--demonstration of Hox-dependent targeting of E2a-Pbx1 in viv

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Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

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Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation

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Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development

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Retroviral gene transfer using safe and efficient packaging cell lines

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Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis

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Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia

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Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

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Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif

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Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism

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Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases.

21 January 2018

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Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

21 January 2018

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Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation

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WNT signalling and haematopoiesis: a WNT-WNT situation

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E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause acute T-lymphoid or myeloid leukemias in mice

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7 January 2021

HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells

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7 January 2021

Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.

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7 January 2021

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

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7 January 2021

Identifiers

DOI

10.1002/DVDY.24056

1 reference

20 December 2017

PubMed ID

23996689

1 reference

20 December 2017