Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality (Q46134175)

http://europepmc.org/abstract/PMC/5461923

19 December 2017

title

Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality (English)

1 reference

http://europepmc.org/abstract/PMC/5461923

19 December 2017

author

Christopher R Butler

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Kevin Ogilvie

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Luis Martinez-Alsina

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Gabriela Barreiro

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Elizabeth M Beck

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Charles E Nolan

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Kevin Atchison

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Eric Benvenuti

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Leanne Buzon

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Shawn Doran

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Cathleen Gonzales

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Christopher J Helal

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Xinjun Hou

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Mei-Hui Hsu

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Eric F Johnson

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Kimberly Lapham

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Lorraine Lanyon

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Kevin Parris

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Brian T O'Neill

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

David Riddell

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Ashley Robshaw

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Felix Vajdos

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Michael A Brodney

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

language of work or name

English

0 references

publication date

20 December 2016

1 reference

http://europepmc.org/abstract/PMC/5461923

19 December 2017

published in

Journal of Medicinal Chemistry

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

60

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

386-402

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents

8 June 2020

cites work

1 reference

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Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.

24 May 2018

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1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads

24 May 2018

1 reference

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Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors

24 May 2018

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Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design

24 May 2018

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Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS.

24 May 2018

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24 May 2018

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BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

24 May 2018

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BACE1 inhibitors: a head group scan on a series of amides

24 May 2018

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β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease

24 May 2018

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

24 May 2018

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24 May 2018

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The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond

24 May 2018

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Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

24 May 2018

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Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

24 May 2018

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24 May 2018

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24 May 2018

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24 May 2018

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24 May 2018

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The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

24 May 2018

1 reference

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BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis

24 May 2018

1 reference

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24 May 2018

1 reference

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Medicinal chemistry of hERG optimizations: Highlights and hang-ups

24 May 2018

1 reference

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24 May 2018

1 reference

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

24 May 2018

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24 May 2018

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24 May 2018

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24 May 2018

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24 May 2018

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24 May 2018

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15 August 2018

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15 August 2018

1 reference

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15 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27997172

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ACS.JMEDCHEM.6B01451

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997172%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference