Controlling miRNA-like off-target effects of an siRNA with nucleobase modifications. (Q46073488)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29164215%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

title

Controlling miRNA-like off-target effects of an siRNA with nucleobase modifications (English)

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3 April 2020

1

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3 April 2020

Andrew J Fisher

7

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3 April 2020

author name string

Alexi Ball-Jones

2

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3 April 2020

Madeline M Mumbleau

3

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3 April 2020

Rachel Valenzuela

4

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3 April 2020

Jose Ibarra-Soza

5

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3 April 2020

Hassan Owens

6

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3 April 2020

Peter A Beal

8

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3 April 2020

publication date

1 December 2017

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Organic and Biomolecular Chemistry

3 April 2020

published in

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3 April 2020

volume

15

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3 April 2020

issue

47

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3 April 2020

page(s)

10029-10036

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Structure-Guided Control of siRNA Off-Target Effects

3 April 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Abasic pivot substitution harnesses target specificity of RNA interference

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Structural basis for microRNA targeting

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Short interfering RNA guide strand modifiers from computational screening.

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Delivery materials for siRNA therapeutics

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

How good are my data and what is the resolution?

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

The Crystal Structure of Human Argonaute2

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Silencing or stimulation? siRNA delivery and the immune system

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing.

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Staying on message: design principles for controlling nonspecific responses to siRNA.

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

PHENIX: a comprehensive Python-based system for macromolecular structure solution

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

MicroRNA-like off-target transcript regulation by siRNAs is species specific.

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Chemically modified siRNA: tools and applications.

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Probing the active site of a diels-alderase ribozyme by photoaffinity cross-linking

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Surprises and pitfalls arising from (pseudo)symmetry

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

MicroRNA targeting specificity in mammals: determinants beyond seed pairing

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Coot: model-building tools for molecular graphics

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Argonaute2 is the catalytic engine of mammalian RNAi

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Expression profiling reveals off-target gene regulation by RNAi

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Calculating the electrostatic properties of RNA provides new insights into molecular interactions and function.

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

Metal-binding sites in the major groove of a large ribozyme domain

7 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5734094

7 October 2018

Identifiers

DOI

10.1039/C7OB02654D

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29164215%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29164215%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference