C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells (Q45885319)

17 December 2017

title

C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells (English)

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17 December 2017

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Kelly M McMasters

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17 December 2017

Robert C G Martin

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object named as

Robert C G Martin

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17 December 2017

author name string

Mary Jane Elliott

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17 December 2017

Ariel Stilwell

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17 December 2017

Yan Bin Dong

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17 December 2017

Hai Liang Yang

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17 December 2017

Sandra L Wong

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17 December 2017

William R Wrightson

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17 December 2017

publication date

1 May 2002

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17 December 2017

published in

Cancer Gene Therapy

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17 December 2017

volume

9

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17 December 2017

issue

5

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17 December 2017

page(s)

453-463

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700458

exact match

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Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

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Differential regulation of E2F transactivation by cyclin/cdk2 complexes

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Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation

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Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

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D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

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Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.

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Role for cyclin A-dependent kinase in DNA replication in human S phase cell extracts

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p21 Disrupts the interaction between cdk2 and the E2F-p130 complex

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Role for the p53 homologue p73 in E2F-1-induced apoptosis

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Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

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E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways

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21 January 2018

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Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

21 January 2018

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E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

21 January 2018

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7 January 2021

Control of E2F activity by p21Waf1/Cip1

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7 January 2021

p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells

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7 January 2021

Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis

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7 January 2021

Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 --> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases.

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7 January 2021

Mutated p21(WAF1/CIP1/SDI1) lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells

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7 January 2021

Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21

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7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700458

1 reference

17 December 2017

Dimensions Publication ID

1004780248

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1 reference

17 December 2017