A receptor-targeted nanocomplex vector system optimized for respiratory gene transfer (Q45876512)

17 December 2017

title

A receptor-targeted nanocomplex vector system optimized for respiratory gene transfer (English)

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17 December 2017

author

Robin J McAnulty

2

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17 December 2017

author name string

Aristides D Tagalakis

1

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17 December 2017

James Devaney

3

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17 December 2017

Stephen E Bottoms

4

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John B Wong

5

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17 December 2017

Martin Elbs

6

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17 December 2017

Michele J Writer

7

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17 December 2017

Helen C Hailes

8

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17 December 2017

Alethea B Tabor

9

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17 December 2017

Christopher O'Callaghan

10

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17 December 2017

Adam Jaffe

11

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17 December 2017

Stephen L Hart

12

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17 December 2017

publication date

25 March 2008

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17 December 2017

published in

Molecular Therapy

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17 December 2017

volume

16

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17 December 2017

issue

5

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17 December 2017

page(s)

907-915

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17 December 2017

Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis

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Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

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7 January 2021

Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus

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Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis

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Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: a two-part clinical study

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A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies.

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Towards safe, non-viral therapeutic gene expression in humans.

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Nonviral gene therapy: promises and challenges

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Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector

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An integrin-targeted non-viral vector for pulmonary gene therapy

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7 January 2021

Cyclooxygenase-2 overexpression, using an integrin-targeted gene delivery system (the LID vector), inhibits fibroblast proliferation in vitro and leads to increased prostaglandin E(2) in the lung.

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7 January 2021

Evaluation of a porcine model for pulmonary gene transfer using a novel synthetic vector

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7 January 2021

High efficiency transfection of porcine vascular cells in vitro with a synthetic vector system

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7 January 2021

Formation of LID vector complexes in water alters physicochemical properties and enhances pulmonary gene expression in vivo

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7 January 2021

Efficient transfection of non-proliferating human airway epithelial cells with a synthetic vector system.

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7 January 2021

Targeted gene delivery to human airway epithelial cells with synthetic vectors incorporating novel targeting peptides selected by phage display

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https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Analysis and optimization of the cationic lipid component of a lipid/peptide vector formulation for enhanced transfection in vitro and in vivo.

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7 January 2021

Gene therapy progress and prospects: cystic fibrosis

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7 January 2021

Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library.

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7 January 2021

Binding and internalization of microorganisms by integrin receptors

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7 January 2021

Functions of pulmonary epithelial integrins: from development to disease

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7 January 2021

The major human rhinovirus receptor is ICAM-1

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7 January 2021

Identification of transfected cell types following non-viral gene transfer to the murine lung.

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7 January 2021

Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung.

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https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Side-effects of a systemic injection of linear polyethylenimine-DNA complexes

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Polyethylenimine-based intravenous delivery of transgenes to mouse lung.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo

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https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungs

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Transfection of airway epithelium by stable PEGylated poly-L-lysine DNA nanoparticles in vivo

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https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Contribution of Plasmid DNA to Inflammation in the Lung after Administration of Cationic Lipid:pDNA Complexes

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Pulmonary cytokine responses associated with PEI-DNA aerosol gene therapy

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https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Asymmetric synthesis of dialkyloxy-3-alkylammonium cationic lipids.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Established cell lines used in cystic fibrosis research

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

The use of absorption enhancers to enhance the dispersibility of spray-dried powders for pulmonary gene therapy.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Increased cystic fibrosis transmembrane conductance regulator (CFTR) expression in the human hydrosalpinx.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.38

7 January 2021

Identifiers

DOI

10.1038/MT.2008.38

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17 December 2017

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17 December 2017