An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia. (Q45874701)

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4 March 2020

title

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia (English)

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4 March 2020

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Alfica Sehgal

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Brian Cooley

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language of work or name

English

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publication date

13 April 2015

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4 March 2020

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volume

21

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4 March 2020

issue

5

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4 March 2020

page(s)

492-497

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https://scigraph.springernature.com/pub.10.1038/nm.3847

4 March 2020

exact match

0 references

cites work

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Milder clinical presentation of haemophilia A with severe deficiency of factor VIII as measured by one-stage assay

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Effects of the factor V G1691A mutation and the factor II G20210A variant on the clinical expression of severe hemophilia A in children--results of a multicenter studys

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Contribution of natural anticoagulant and fibrinolytic factors in modulating the clinical severity of haemophilia patients.

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1 reference

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1 reference

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1 reference

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1 reference

Heterozygous antithrombin deficiency improves in vivo haemostasis in factor VIII-deficient mice.

21 January 2018

1 reference

Inhibition of antithrombin by protein SV-IV normalizes the coagulation of hemophilic blood

21 January 2018

1 reference

Thrombin generation and phenotypic correlation in haemophilia A.

21 January 2018

1 reference

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21 January 2018

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21 January 2018

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21 January 2018

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Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A.

21 January 2018

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A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia

21 January 2018

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21 January 2018

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Phosphatidylinositol containing lipidic particles reduces immunogenicity and catabolism of factor VIII in hemophilia a mice

21 January 2018

1 reference

A sensitive venous bleeding model in haemophilia A mice: effects of two recombinant FVIII products (N8 and Advate(®)).

21 January 2018

1 reference

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21 January 2018

1 reference

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21 January 2018

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21 January 2018

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21 January 2018

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Calibrated automated thrombin generation measurement in clotting plasma

21 January 2018

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21 January 2018

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12 December 2020

Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse

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12 December 2020

Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B.

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12 December 2020

Monoclonal antibodies to a synthetic fibrin-like peptide bind to human fibrin but not fibrinogen

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12 December 2020

Symptomatic onset of severe hemophilia A in childhood is dependent on the presence of prothrombotic risk factors

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12 December 2020

Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing

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12 December 2020

Effect of the factor V Leiden mutation on the clinical expression of severe hemophilia A.

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12 December 2020

Gene-gene and gene-environment interactions determine risk of thrombosis in families with inherited antithrombin deficiency

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12 December 2020

Risk of venous thromboembolism in relatives of symptomatic probands with thrombophilia: a systematic review

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12 December 2020