ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis. (Q45840288)

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8 February 2020

title

ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis (English)

1 reference

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8 February 2020

0 references

8

1 reference

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8 February 2020

Claudia Cerella

2

1 reference

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8 February 2020

6

Marc Schumacher

1 reference

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8 February 2020

3

Fabienne Mack

1 reference

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8 February 2020

1

Mareike Kelkel

1 reference

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8 February 2020

author name string

Thomas Schneider

4

1 reference

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8 February 2020

Claus Jacob

5

1 reference

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8 February 2020

Mario Dicato

7

1 reference

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8 February 2020

language of work or name

English

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publication date

20 July 2012

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8 February 2020

1 reference

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8 February 2020

volume

33

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8 February 2020

issue

11

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8 February 2020

page(s)

2162-2171

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Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds

8 February 2020

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Cell cycle arrest in early mitosis and induction of caspase-dependent apoptosis in U937 cells by diallyltetrasulfide (Al2S4).

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c-Jun NH(2)-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells

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Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak

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Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C.

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Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways

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Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin

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Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells

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Multistep and multitask Bax activation

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Bcl-2 phosphorylation required for anti-apoptosis function

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Inactivation of Bcl-2 by phosphorylation

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UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

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Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis.

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Apoptosis induction in human lung adenocarcinoma cells by oil-soluble allyl sulfides: triggers, pathways, and modulators

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Cellular glutathione and thiols metabolism.

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COX-2 inhibitors block chemotherapeutic agent-induced apoptosis prior to commitment in hematopoietic cancer cells

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Microtubule assembly dynamics: an attractive target for anticancer drugs

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Polysulfides as biologically active ingredients of garlic

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Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

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Docetaxel-induced apoptosis of human melanoma is mediated by activation of c-Jun NH2-terminal kinase and inhibited by the mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway

21 January 2018

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Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells

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Apoptosis induced by diallyl disulfide in human breast cancer cell line MCF-7.

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Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

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Molecular mechanism of diallyl disulfide in cell cycle arrest and apoptosis in HCT-116 colon cancer cells

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Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis

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Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells

21 January 2018

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