Evidence for polygenic adaptation to pathogens in the human genome (Q45718642)

15 December 2017

Evidence for polygenic adaptation to pathogens in the human genome (English)

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15 December 2017

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5

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15 December 2017

Marc Robinson-Rechavi

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15 December 2017

7

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15 December 2017

Josephine T Daub

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author name string

Tamara Hofer

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15 December 2017

Emilie Cutivet

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15 December 2017

Isabelle Dupanloup

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15 December 2017

26 April 2013

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Molecular Biology and Evolution

15 December 2017

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15 December 2017

30

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15 December 2017

7

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15 December 2017

1544-1558

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A general modular framework for gene set enrichment analysis

15 December 2017

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Constructing genomic maps of positive selection in humans: where do we go from here?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Improved scoring of functional groups from gene expression data by decorrelating GO graph structure

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

FatiGO: a web tool for finding significant associations of Gene Ontology terms with groups of genes

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Genomic data reveal a complex making of humans

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Genome-wide scan for signatures of human population differentiation and their relationship with natural selection, functional pathways and diseases

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

The relationship between blood groups and disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Challenges in human genetic diversity: demographic history and adaptation

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Natural selection has driven population differentiation in modern humans

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

From evolutionary genetics to human immunology: how selection shapes host defence genes

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Adaptation and speciation: what can F(st) tell us?

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Sequential Monte Carlo p-values

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Sialic acids in T cell development and function

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Understanding RAGE, the receptor for advanced glycation end products

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Regulation of innate immunity by Rho GTPases

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Bone morphogenetic proteins: a critical review

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

A human genome diversity cell line panel

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

The effects of deleterious mutations on evolution at linked sites

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Stratigraphic, chronological and behavioural contexts of Pleistocene Homo sapiens from Middle Awash, Ethiopia

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Bacterial invasion: the paradigms of enteroinvasive pathogens

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Smurf2 alters BPV1 trafficking and decreases infection

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Improving gene set analysis of microarray data by SAM-GS.

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Identification of a variant associated with adult-type hypolactasia

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Genetic Consequences of Range Expansions

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Detecting loci under selection in a hierarchically structured population

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

An evolutionary history of the selectin gene cluster in humans.

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

The NCBI BioSystems database

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Trans genomic capture and sequencing of primate exomes reveals new targets of positive selection

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Adaptations to new environments in humans: the role of subtle allele frequency shifts

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Adaptations to climate-mediated selective pressures in humans

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Colloquium paper: human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Evidence for variable selective pressures at MC1R

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Mini-review: The nuclear protein HMGB1 as a proinflammatory mediator

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Dengue virus-induced autophagy regulates lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Population genetics of malaria resistance in humans

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Immune regulation by the ST6Gal sialyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Classic selective sweeps were rare in recent human evolution

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Evolutionary forces shaping genomic islands of population differentiation in humans

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

GSEA-SNP: applying gene set enrichment analysis to SNP data from genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Detecting local adaptation using the joint sampling of polymorphism data in the parental and derived populations

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

A scan for signatures of positive selection in candidate loci for skin pigmentation in humans

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

KEGG for integration and interpretation of large-scale molecular data sets

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

A Genome Scan to Detect Candidate Regions Influenced by Local Natural Selection in Human Populations

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Human population differentiation is strongly correlated with local recombination rate

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

PAGE: parametric analysis of gene set enrichment

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

IL-6: from its discovery to clinical applications

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Circos: an information aesthetic for comparative genomics

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

A role for alpha-and beta-catenins in bacterial uptake

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Worldwide human relationships inferred from genome-wide patterns of variation

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Systematic identification of type I and type II interferon-induced antiviral factors

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Entrez Gene: gene-centered information at NCBI

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Evolutionary genetic dissection of human interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Reactome knowledgebase of human biological pathways and processes

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Stratigraphic placement and age of modern humans from Kibish, Ethiopia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Enrichment map: a network-based method for gene-set enrichment visualization and interpretation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

GSA-SNP: a general approach for gene set analysis of polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

E-cadherin: gatekeeper of airway mucosa and allergic sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Recent and ongoing selection in the human genome

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Genomic scans for selective sweeps using SNP data

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Searching for footprints of positive selection in whole-genome SNP data from nonequilibrium populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

A critical assessment of storytelling: gene ontology categories and the importance of validating genomic scans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Host-mediated regulation of superinfection in malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Standardized subsets of the HGDP-CEPH Human Genome Diversity Cell Line Panel, accounting for atypical and duplicated samples and pairs of close relatives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Genetic structure of human populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Role of Rac1 in Escherichia coli K1 invasion of human brain microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Variation in Human Body Size and Shape

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Genome-wide detection and characterization of positive selection in human populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

PID: the Pathway Interaction Database

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Enteropathogenic Escherichia coli type III effectors EspG and EspG2 disrupt the microtubule network of intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Cytoscape 2.8: new features for data integration and network visualization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Statistical significance for genomewide studies

21 January 2018

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https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Genome scans of DNA variability in humans reveal evidence for selective sweeps outside of Africa

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Progress and promise of genome-wide association studies for human complex trait genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

GSEA-P: a desktop application for Gene Set Enrichment Analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

The cell biology of vision

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Gene set analyses for interpreting microarray experiments on prokaryotic organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Comparing gene set analysis methods on single-nucleotide polymorphism data from Genetic Analysis Workshop 16.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Vav-family proteins in T-cell signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Lipids in host-pathogen interactions: pathogens exploit the complexity of the host cell lipidome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Roles of galectins in infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Vav proteins regulate peripheral B-cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

A map of recent positive selection in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Global landscape of recent inferred Darwinian selection for Homo sapiens

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Pathway-based approaches for analysis of genomewide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Mammalian G proteins and their cell type specific functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Localizing recent adaptive evolution in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Exploiting host microtubule dynamics: a new aspect of bacterial invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Differential susceptibility to hypertension is due to selection during the out-of-Africa expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

An investigation of the statistical power of neutrality tests based on comparative and population genetic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

Estimating the number of true null hypotheses from a histogram of p values

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMST080

21 January 2018

Identifiers

DOI

10.1093/MOLBEV/MST080

1 reference

15 December 2017

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