Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination (Q45346807)

13 December 2017

Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination (English)

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13 December 2017

M Krajewska

1

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13 December 2017

A M Heijink

2

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13 December 2017

Y J W M Bisselink

3

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13 December 2017

R I Seinstra

4

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13 December 2017

H H W Silljé

5

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13 December 2017

E G E de Vries

6

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13 December 2017

M A T M van Vugt

7

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13 December 2017

language of work or name

English

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publication date

16 July 2012

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13 December 2017

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13 December 2017

32

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13 December 2017

3001-3008

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13 December 2017

24

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https://scigraph.springernature.com/pub.10.1038/onc.2012.296

13 December 2017

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Cdc2 regulatory factors

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

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WAF1, a potential mediator of p53 tumor suppression

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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p53 in health and disease

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Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination

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CDK targets Sae2 to control DNA-end resection and homologous recombination

21 January 2018

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DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

21 January 2018

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Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.

21 January 2018

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Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

21 January 2018

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Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery

21 January 2018

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A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint

21 January 2018

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Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease

21 January 2018

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MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo

21 January 2018

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Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

21 January 2018

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MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts

21 January 2018

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Universal control mechanism regulating onset of M-phase

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Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

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Overall Cdk activity modulates the DNA damage response in mammalian cells

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In my end is my beginning: control of end resection and DSBR pathway 'choice' by cyclin-dependent kinases

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Cell cycle re-entry mechanisms after DNA damage checkpoints: giving it some gas to shut off the breaks!

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DNA end joining becomes less efficient and more error-prone during cellular senescence

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ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells

21 January 2018

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XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

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Roscovitine modulates DNA repair and senescence: implications for combination chemotherapy.

21 January 2018

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Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents

21 January 2018

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Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells

21 January 2018

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Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF.

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An overview of Cdk1-controlled targets and processes

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CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

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Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage

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Arrest, adaptation, and recovery following a chromosome double-strand break in Saccharomyces cerevisiae

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Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase

21 January 2018

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CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.

21 January 2018

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Targets of the cyclin-dependent kinase Cdk1

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.296

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.296

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.296

CDC5 and CKII control adaptation to the yeast DNA damage checkpoint

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.296

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.296

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Dimensions Publication ID

13 December 2017

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