The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling. (Q45345537)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24880459%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling (English)

1 reference

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Suppressor of cytokine signaling 1

19 March 2020

main subject

1 reference

Zinc finger and BTB domain containing 7B

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Jung Hyun Park

6

1 reference

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19 March 2020

author name string

Megan A Luckey

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24880459%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Motoko Y Kimura

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24880459%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Adam T Waickman

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24880459%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Lionel Feigenbaum

4

1 reference

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19 March 2020

Alfred Singer

5

1 reference

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19 March 2020

language of work or name

English

0 references

publication date

1 June 2014

1 reference

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19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24880459%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

volume

15

1 reference

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19 March 2020

issue

7

1 reference

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19 March 2020

page(s)

638-645

1 reference

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Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice

19 March 2020

cites work

1 reference

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.

21 January 2018

1 reference

Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes

21 January 2018

1 reference

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

21 January 2018

1 reference

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.

21 January 2018

1 reference

CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus.

21 January 2018

1 reference

Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

21 January 2018

1 reference

Transcriptional and epigenetic regulation of CD4/CD8 lineage choice.

21 January 2018

1 reference

The enigma of CD4-lineage specification

21 January 2018

1 reference

SOCS proteins, cytokine signalling and immune regulation

21 January 2018

1 reference

HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells

21 January 2018

1 reference

Regulation of lineage commitment distinct from positive selection.

21 January 2018

1 reference

The role of ThPOK in control of CD4/CD8 lineage commitment

21 January 2018

1 reference

Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells

21 January 2018

1 reference

Coreceptor gene imprinting governs thymocyte lineage fate.

21 January 2018

1 reference

SOCS regulation of the JAK/STAT signalling pathway

21 January 2018

1 reference

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

21 January 2018

1 reference

Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.

21 January 2018

1 reference

Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells.

21 January 2018

1 reference

Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

21 January 2018

1 reference

Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells

21 January 2018

1 reference

A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.

21 January 2018

1 reference

The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells

21 January 2018

1 reference

Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice

21 January 2018

1 reference

ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage

21 January 2018

1 reference

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

21 January 2018

1 reference

SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

21 January 2018

1 reference

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24880459

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24880459

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.2917

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24880459%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

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19 March 2020

PubMed publication ID

24880459

1 reference