Oxidative Stress Induced Senescence (Q45314178)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2559580)

Language	Label	Description	Also known as
English	Oxidative Stress Induced Senescence	An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2559580)

Statements

instance of

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8 July 2022

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-2559580

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8 July 2022

MDM2 ubiquitinates TP53

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8 July 2022

Association of INK4 family proteins with CDK4/6

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8 July 2022

miR-24 binds p16INK4A and p14ARF mRNAs

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8 July 2022

Translation of p14ARF mRNA is inhibited by miR-24

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8 July 2022

Translation of p16INK4A mRNA is inhibited by miR-24

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8 July 2022

p14ARF forms a ternary complex with MDM2 and TP53

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8 July 2022

p14ARF sequesters MDM2

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8 July 2022

RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS)

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8 July 2022

ROS oxidize thioredoxin and activate MAP3K5

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8 July 2022

Expression of MINK1/TNIK is positively regulated by ROS

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8 July 2022

MAP3K5 phosphorylates MKK3 and MKK6

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8 July 2022

Phosphorylated MKK3/MKK6 migrates to nucleus

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8 July 2022

Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3

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8 July 2022

Active p38 MAPK phosphorylates MAPKAPK2 or 3

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8 July 2022

MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)

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8 July 2022

Phosphorylation of human JNKs by activated MKK4/MKK7

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8 July 2022

Activated human JNKs migrate to nucleoplasm

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8 July 2022

Activated JNKs phosphorylate c-JUN

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8 July 2022

c-FOS activation by phospho ERK1/2

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8 July 2022

Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.

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8 July 2022

E2F1/2/3:DP1/2 binds EED gene promoter

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8 July 2022

E2F1/2/3 stimulates EED transcription

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8 July 2022

E2F1/2/3:DP1/2 binds EZH2 gene promoter

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8 July 2022

E2F1/2/3 stimulates EZH2 transcription

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8 July 2022

E2F1/2/3:DP1/2 binds SUZ12 gene promoter

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8 July 2022

E2F1/2/3 stimulates SUZ12 transcription

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8 July 2022

Formation of PRC2-EZH2 complex

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8 July 2022

PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter

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8 July 2022

ERK1/2-activated AP1 complex binds KDM6B promoter

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8 July 2022

PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter

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8 July 2022

p-MAPKAPK3 phosphorylates BMI1

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8 July 2022

MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription

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8 July 2022

AP-1 complex stimulates KDM6B transcription

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8 July 2022

KDM6B demethylates H3K27me3 on p16INK4A promoter

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8 July 2022

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8 July 2022

Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription

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8 July 2022

Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5

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8 July 2022

MAPKAPK5 phosphorylates TP53

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8 July 2022

Active p38 MAPK phosphorylates MAPKAPK5

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8 July 2022

p14ARF translocates to the nucleus

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8 July 2022

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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8 July 2022

PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes

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8 July 2022

3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region

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8 July 2022

A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress

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8 July 2022

Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade

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8 July 2022

Regulatory mechanisms involved in activator-protein-1 (AP-1)-mediated activation of glutathione-S-transferase gene expression by chemical agents

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8 July 2022

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

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8 July 2022

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

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8 July 2022

Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

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8 July 2022

Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells

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8 July 2022

Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence

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8 July 2022

Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis.

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8 July 2022

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

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8 July 2022

PRAK, a novel protein kinase regulated by the p38 MAP kinase

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8 July 2022

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7

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8 July 2022

DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation

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8 July 2022

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

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8 July 2022

Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases

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8 July 2022

MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1

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8 July 2022

Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo

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8 July 2022

Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus

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8 July 2022

Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2

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8 July 2022

Use of chromatin immunoprecipitation to clone novel E2F target promoters

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8 July 2022

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

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8 July 2022

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

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8 July 2022

The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells

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8 July 2022

pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

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8 July 2022

PRAK is essential for ras-induced senescence and tumor suppression

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8 July 2022

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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8 July 2022

Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase

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8 July 2022

Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export

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8 July 2022

Molecular basis of MAPK-activated protein kinase 2:p38 assembly

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8 July 2022

Molecular interpretation of ERK signal duration by immediate early gene products

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8 July 2022

Regulation of PRAK subcellular location by p38 MAP kinases

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8 July 2022

Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA

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8 July 2022

A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion

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8 July 2022

Catalysis and function of the p38 alpha.MK2a signaling complex

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8 July 2022

Mitochondrial dysfunction contributes to oncogene-induced senescence.

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8 July 2022

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

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8 July 2022

Identifiers

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8 July 2022

Oxidative Stress Induced Senescence (Q45314178)

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Oxidative Stress Induced Senescence (Q45314178)

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