Differential morphology and composition of inclusions in the R6/2 mouse and PC12 cell models of Huntington's disease. (Q45304103)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17285342%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

title

Differential morphology and composition of inclusions in the R6/2 mouse and PC12 cell models of Huntington's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17285342%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

0 references

Jonathan Porter Wanderer

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17285342%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

2

A Jennifer Morton

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17285342%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

publication date

7 February 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17285342%20AND%20SRC:MED&resulttype=core&format=json

Histochemistry and Cell Biology

25 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17285342%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

volume

127

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17285342%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17285342%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

page(s)

473-484

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17285342%20AND%20SRC:MED&resulttype=core&format=json

Neuronal intranuclear inclusions and neuropil aggregates in HdhCAG(150) knockin mice

25 December 2019

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00418-007-0272-Z

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00418-007-0272-Z

Protein degradation and protection against misfolded or damaged proteins

21 January 2018

1 reference

12 December 2020

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

1 reference

12 December 2020

Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGgamma as a therapeutic target

1 reference

12 December 2020

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

1 reference

12 December 2020

Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons

1 reference

12 December 2020

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

12 December 2020

Mice transgenic for the human Huntington's disease mutation have reduced sensitivity to kainic acid toxicity

1 reference

12 December 2020

Purification of neuronal inclusions of patients with Huntington's disease reveals a broad range of N-terminal fragments of expanded huntingtin and insoluble polymers

1 reference

12 December 2020

Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice

1 reference

12 December 2020

Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells

1 reference

12 December 2020

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

1 reference

12 December 2020

Calmodulin regulates transglutaminase 2 cross-linking of huntingtin.

1 reference

12 December 2020

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

1 reference

12 December 2020

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

12 December 2020

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

1 reference

12 December 2020

Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity.

1 reference

12 December 2020

Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain.

1 reference

12 December 2020

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

12 December 2020

Tissue transglutaminase does not contribute to the formation of mutant huntingtin aggregates

1 reference

12 December 2020

Spine growth precedes synapse formation in the adult neocortex in vivo.

1 reference

12 December 2020

Protein aggregation and neurodegenerative disease

1 reference

12 December 2020

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

12 December 2020

Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation

1 reference

12 December 2020

Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse

1 reference

12 December 2020

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

1 reference

12 December 2020

Pathogenesis of polyglutamine disorders: aggregation revisited

1 reference

12 December 2020

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

1 reference

12 December 2020

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

1 reference

12 December 2020

Subcellular localization of proteasomes and their regulatory complexes in mammalian cells.

1 reference

12 December 2020

Proteasome degrades soluble expanded polyglutamine completely and efficiently

1 reference

12 December 2020

Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.

1 reference

12 December 2020

Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain

1 reference

12 December 2020

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

1 reference

12 December 2020

Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

1 reference

12 December 2020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

12 December 2020

Diseases of unstable repeat expansion: mechanisms and common principles

1 reference

12 December 2020