The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1. (Q45291223)

11 December 2017

The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1. (English)

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11 December 2017

Ying Wang

1

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11 December 2017

Robyn Branicky

2

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11 December 2017

Zaruhi Stepanyan

3

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11 December 2017

Melissa Carroll

4

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11 December 2017

Marie-Pierre Guimond

5

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11 December 2017

Abdelmadjid Hihi

6

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11 December 2017

Steve Hayes

7

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11 December 2017

Kevin McBride

8

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11 December 2017

Siegfried Hekimi

9

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11 December 2017

language of work or name

English

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publication date

15 October 2008

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Journal of Biological Chemistry

11 December 2017

10

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based on heuristic

inferred from page(s)

published in

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11 December 2017

284

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11 December 2017

1

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11 December 2017

314-323

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Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice

11 December 2017

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https://api.crossref.org/works/10.1074%2FJBC.M807579200

Metabolism and function of coenzyme Q.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M807579200

Early mitochondrial dysfunction in long-lived Mclk1+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Determination of life-span in Caenorhabditis elegans by four clock genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

The genetics of caloric restriction in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

The plasticity of aging: insights from long-lived mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

How genetic analysis tests theories of animal aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Brain IRS2 signaling coordinates life span and nutrient homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Sensitivity of Caenorhabditis elegans clk-1 mutants to ubiquinone side-chain length reveals multiple ubiquinone-dependent processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Clioquinol treatment in familiar early onset of Alzheimer's disease: a case report

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Treatment of Alzheimer's disease with clioquinol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Metal-protein attenuating compounds and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Uncoupling the pleiotropic phenotypes of clk-1 with tRNA missense suppressors in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Measuring nitric oxide and superoxide: rate constants for aconitase reactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

The COQ7 gene encodes a protein in saccharomyces cerevisiae necessary for ubiquinone biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

A new member of the family of di-iron carboxylate proteins. Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Ubiquinone (coenzyme Q) biosynthesis in Escherichia coli: identification of the ubiF gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807579200

21 January 2018

Identifiers

DOI

10.1074/JBC.M807579200

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11 December 2017

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