Cytosolic phospholipase A2alpha regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation (Q45271816)

11 December 2017

Cytosolic phospholipase A2alpha regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation (English)

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11 December 2017

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Adam Sapirstein

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11 December 2017

Hideyuki Saito

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11 December 2017

Sarah J Texel

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11 December 2017

Tarek A Samad

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Eileen O'Leary

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11 December 2017

Joseph V Bonventre

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17 February 2005

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American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

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288

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6

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R1774-82

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Group V phospholipase A(2)-dependent induction of cyclooxygenase-2 in macrophages

11 December 2017

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Neuroinflammation in Alzheimer's disease and prion disease.

21 January 2018

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Inflammatory response: pathway across the blood-brain barrier.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Prostaglandin E(2) regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Inhibitors of intracellular phospholipase A2 activity: their neurochemical effects and therapeutical importance for neurological disorders

21 January 2018

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Cytosolic phospholipase A2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells

21 January 2018

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Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression

21 January 2018

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Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Neurovascular regulation in the normal brain and in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Brain-specific endothelial induction of prostaglandin E(2) synthesis enzymes and its temporal relation to fever

21 January 2018

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Cytosolic phospholipase A2 plays a key role in the pathogenesis of multiple sclerosis-like disease

21 January 2018

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A natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains

21 January 2018

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Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1beta

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2(-/-), but not in cyclooxygenase-1(-/-) mice

21 January 2018

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Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Intraparenchymal administration of interleukin-1beta induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2.

21 January 2018

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Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Brain lipid metabolism in the cPLA2 knockout mouse

21 January 2018

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Rat brain arachidonic acid metabolism is increased by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide

21 January 2018

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Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

21 January 2018

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Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenase-2 expression in neocortex

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Neuronal overexpression of COX-2 results in dominant production of PGE2 and altered fever response

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Group-specific assays that distinguish between the four major types of mammalian phospholipase A2.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

Collateral damage repaired

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https://api.crossref.org/works/10.1152%2FAJPREGU.00815.2004

10.1152/AJPREGU.00815.2004

21 January 2018

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DOI

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11 December 2017

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