Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation (Q45240553)

11 December 2017

Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation (English)

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chronic lymphocytic leukemia

11 December 2017

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9

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W J M Mackus

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A P Kater

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A Grummels

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L M Evers

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B Hooijbrink

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M H H Kramer

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J E Castro

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T J Kipps

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M H J van Oers

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E Eldering

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1 March 2005

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19

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427-434

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3

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2403623

11 December 2017

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Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

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Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

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Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.

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Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

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PUMA, a novel proapoptotic gene, is induced by p53

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PUMA induces the rapid apoptosis of colorectal cancer cells

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Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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BID regulation by p53 contributes to chemosensitivity

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Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia.

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Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses.

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Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response

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Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification

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Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways

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Aberrant expression and reverse signalling of CD70 on malignant B cells

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Prevention of B cell antigen receptor-induced apoptosis by ligation of CD40 occurs downstream of cell cycle regulation.

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Transcriptional analysis of the B cell germinal center reaction

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

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B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes

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NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

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Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

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CD40 stimulation of B-cell chronic lymphocytic leukaemia cells enhances the anti-apoptotic profile, but also Bid expression and cells remain susceptible to autologous cytotoxic T-lymphocyte attack.

21 January 2018

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Bcl-2 family gene modulation during spontaneous apoptosis of B-chronic lymphocytic leukemia cells

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Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

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Integral role of Noxa in p53-mediated apoptotic response

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p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation

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7 January 2021

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

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7 January 2021

Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro

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7 January 2021

P53, MDM-2, BAX and BCL-2 and drug resistance in chronic lymphocytic leukemia

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403623

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Dimensions Publication ID

11 December 2017

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