Endoproteolytic cleavage of FE65 converts the adaptor protein to a potent suppressor of the sAPPalpha pathway in primates (Q45221632)

11 December 2017

Endoproteolytic cleavage of FE65 converts the adaptor protein to a potent suppressor of the sAPPalpha pathway in primates (English)

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11 December 2017

Qubai Hu

1

1 reference

11 December 2017

Lin Wang

2

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11 December 2017

Zheng Yang

3

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11 December 2017

Bethany H Cool

4

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11 December 2017

Galynn Zitnik

5

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11 December 2017

George M Martin

6

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11 December 2017

language of work or name

English

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publication date

12 January 2005

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Journal of Biological Chemistry

11 December 2017

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11 December 2017

280

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11 December 2017

13

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11 December 2017

12548-12558

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Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein

11 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

A candidate molecular mechanism for the association of an intronic polymorphism of FE65 with resistance to very late onset dementia of the Alzheimer type

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Alternatively spliced isoforms of FE65 serve as neuron-specific and non-neuronal markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Expression of the Fe65 adapter protein in adult and developing mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Isoform-specific knockout of FE65 leads to impaired learning and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

hFE65L influences amyloid precursor protein maturation and secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

A cell biological perspective on Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Extracellular matrix influences the biogenesis of amyloid precursor protein in microglial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Gamma-secretase: proteasome of the membrane?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

The deletion of the C-terminal tail and addition of an endoplasmic reticulum targeting signal to Alzheimer's amyloid precursor protein change its localization, secretion, and intracellular proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

A basic amino acid in the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein (APP) is essential for cleavage of APP at the alpha-site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Increased expression of beta-amyloid protein precursor and microtubule-associated protein tau during the differentiation of murine embryonal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Mutational analysis of the membrane-proximal cleavage site of L-selectin: relaxed sequence specificity surrounding the cleavage site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

A long acidic domain affects the chromatographic behaviour of a neuronal adaptor protein on DEAE-Sepharose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

Expression of the neuron-specific FE65 gene marks the development of embryo ganglionic derivatives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411855200

21 January 2018

Identifiers

DOI

10.1074/JBC.M411855200

1 reference

11 December 2017

1 reference