Treatment with simvastatin suppresses the development of experimental abdominal aortic aneurysms in normal and hypercholesterolemic mice. (Q45204273)

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6 January 2020

title

Treatment with simvastatin suppresses the development of experimental abdominal aortic aneurysms in normal and hypercholesterolemic mice (English)

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Eric F Steinmetz

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Celine Buckley

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Murray L Shames

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Terri L Ennis

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Sarah J Vanvickle-Chavez

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Dongli Mao

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Lee A Goeddel

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Cherady J Hawkins

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Robert W Thompson

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language of work or name

English

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publication date

1 January 2005

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volume

241

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issue

1

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page(s)

92-101

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Effects of hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin on smooth muscle cell proliferation in vitro and neointimal formation in vivo after vascular injury

6 January 2020

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Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms

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Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits urokinase/urokinase-receptor expression and MMP-9 secretion by peripheral blood monocytes--a possible protective mechanism against atherothrombosis

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Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering

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Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors

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Simvastatin inhibits expression of tissue factor in advanced atherosclerotic lesions of apolipoprotein E deficient mice independently of lipid lowering: potential role of simvastatin-mediated inhibition of Egr-1 expression and activation

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Transient exposure to elastase induces mouse aortic wall smooth muscle cell production of MCP-1 and RANTES during development of experimental aortic aneurysm.

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An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro

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Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase

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Anti-atherosclerotic effect of simvastatin depends on the presence of apolipoprotein E.

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Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice

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Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration

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Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages

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The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms

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3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)

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A 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, cerivastatin, suppresses production of matrix metalloproteinase-9 in human abdominal aortic aneurysm wall

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Simvastatin promotes atherosclerotic plaque stability in apoE-deficient mice independently of lipid lowering

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Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages

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12 December 2020

10.1097/01.SLA.0000150258.36236.E0

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15621996%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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