Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer (Q45119723)

9 December 2017

Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer (English)

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9 December 2017

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Mark A Rochester

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9 December 2017

Johann Riedemann

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9 December 2017

Giles O Hellawell

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9 December 2017

Simon F Brewster

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9 December 2017

Valentine M Macaulay

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9 December 2017

1 January 2005

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90-100

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https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700775

9 December 2017

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Insulin-like Growth Factor I Increases αVβ3Affinity by Increasing the Amount of Integrin-associated Protein That Is Associated with Non-raft Domains of the Cellular Membrane

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Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines

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Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin

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Blockade of the type I IGF receptor expression in human prostate cancer cells inhibits proliferation and invasion, up-regulates IGF binding protein-3, and suppresses MMP-2 expression

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7 January 2021

Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo

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Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

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7 January 2021

IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation

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7 January 2021

Chemosensitization of human prostate cancer using antisense agents targeting the type 1 insulin-like growth factor receptor

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7 January 2021

The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript

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7 January 2021

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase

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Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.

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Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

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Kinetics of hydrolysis in vitro of nornitrogen mustard, a metabolite of phosphoramide mustard and cyclophosphamide

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Insulin-like growth factor I: action and receptor characterization in human prostate cancer cell lines

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PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells

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7 January 2021

Multiple signaling pathways are involved in the regulation of IGF-I receptor inhibition of PTEN-enhanced apoptosis

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7 January 2021

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

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7 January 2021

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis

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7 January 2021

Insulin-like growth factor (IGF) system components in human prostatic cancer cell-lines: LNCaP, DU145, and PC-3 cells

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7 January 2021

Recruitment of focal adhesion kinase and paxillin to beta1 integrin promotes cancer cell migration via mitogen activated protein kinase activation

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Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin

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7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

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Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

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7 January 2021

Insulin-like growth factor-1 activates Akt and Jun N-terminal kinases (JNKs) in promoting the survival of T lymphocytes

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Multiple pathways are involved in protection of MCF-7 cells against death due to protein synthesis inhibition.

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7 January 2021

Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death--proliferative and anti-apoptotic effects

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7 January 2021

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7 January 2021

Regulation and mechanisms of mammalian double-strand break repair

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7 January 2021

Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.

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7 January 2021

Blockage of IGF-1R signaling sensitizes urinary bladder cancer cells to mitomycin-mediated cytotoxicity

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7 January 2021

Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells.

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7 January 2021

Effectiveness of insulin-like growth factor I receptor antisense strategy against Ewing's sarcoma cells

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7 January 2021

Ewing tumour: incidence, prognosis and treatment options

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7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700775

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Dimensions Publication ID

9 December 2017

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