Evidence of biased immunoglobulin variable gene usage in highly stable B-cell chronic lymphocytic leukemia. (Q45106454)

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4 January 2020

title

Evidence of biased immunoglobulin variable gene usage in highly stable B-cell chronic lymphocytic leukemia (English)

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4 January 2020

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4 January 2020

Francesca Romana Mauro

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4 January 2020

author name string

Guarini A

2

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Berra E

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Rossi D

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Ghia E

6

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Cerri M

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Logan J

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Foà R

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Gaidano G

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publication date

1 December 2004

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4 January 2020

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4 January 2020

volume

18

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issue

12

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page(s)

1941-1947

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2403537

4 January 2020

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cites work

ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.

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Chronic lymphocytic leukemia: revelations from the B-cell receptor.

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Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

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Normal B cells express 51p1-encoded Ig heavy chains that are distinct from those expressed by chronic lymphocytic leukemia B cells

21 January 2018

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Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia

21 January 2018

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Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire

21 January 2018

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Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope.

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Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia

21 January 2018

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Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

21 January 2018

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Ig V region restrictions in human chronic lymphocytic leukemia suggest some cases have a common origin

21 January 2018

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Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.

21 January 2018

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Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination

21 January 2018

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The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

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The inference of antigen selection on Ig genes

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Analysis of human VH gene repertoire expression in peripheral CD19+ B cells.

21 January 2018

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Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells

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Immunoglobulin VH gene expression in human aging

21 January 2018

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A directory of human germ-line V kappa segments reveals a strong bias in their usage

21 January 2018

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Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells

21 January 2018

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The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops

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The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus

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Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences.

21 January 2018

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The diversity of rearranged immunoglobulin heavy chain variable region genes in peripheral blood B cells of preterm infants is restricted by short third complementarity-determining regions but not by limited gene segment usage

21 January 2018

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Unsolved issues in CLL biology and management

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7 January 2021

Biology and treatment of chronic lymphocytic leukemia

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7 January 2021

Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features

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7 January 2021

Molecular histogenesis of posttransplantation lymphoproliferative disorders

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403537

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15483675%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

4 January 2020

1035616661

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1 reference