Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism (Q45081990)

9 December 2017

Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism (English)

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9 December 2017

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10

Stanley H Appel

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9 December 2017

Albert A Yen

8

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author name string

Weihua Zhao

1

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9 December 2017

Wenjie Xie

2

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9 December 2017

Weidong Le

3

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9 December 2017

David R Beers

4

1 reference

9 December 2017

Yi He

5

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9 December 2017

Jenny S Henkel

6

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9 December 2017

Ericka P Simpson

7

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9 December 2017

Qin Xiao

9

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9 December 2017

1 September 2004

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Journal of Neuropathology & Experimental Neurology

9 December 2017

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9 December 2017

63

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9 December 2017

9

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9 December 2017

964-977

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Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS.

9 December 2017

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Microglia: a sensor for pathological events in the CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Activated microglia (BV-2) facilitation of TNF-alpha-mediated motor neuron death in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Minocycline delays disease onset and mortality in a transgenic model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Reactive astrocytes are widespread in the cortical gray matter of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

GLT-1 glutamate transporter levels are unchanged in mice expressing G93A human mutant SOD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Glial cells potentiate kainate-induced neuronal death in a motoneuron-enriched spinal coculture system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Astrocytic factors protect neuronal integrity and reduce microglial activation in an in vitro model of N-methyl-D-aspartate-induced excitotoxic injury in organotypic hippocampal slice cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Glial cells protect neurons against oxidative stress via transcriptional up-regulation of the glutathione synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Transforming growth factor beta's 1, 2 and 3 inhibit proliferation of ramified microglia on an astrocyte monolayer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Tissue-type plasminogen activator is not required for kainate-induced motoneuron death in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Effects of estrogen treatment on glutamate uptake in cultured human astrocytes derived from cortex of Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Motor neurons rapidly accumulate DNA single-strand breaks after in vitro exposure to nitric oxide and peroxynitrite and in vivo axotomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Reactive microglia in multiple sclerosis lesions have an increased expression of receptors for the Fc part of IgG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Role of Fcgamma receptors in nigral cell injury induced by Parkinson disease immunoglobulin injection into mouse substantia nigra

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Stereotaxic injection of IgG from patients with Alzheimer disease initiates injury of cholinergic neurons of the basal forebrain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Serum and CSF immunological findings in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Evidence for immune-complex formation in patients with amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Protective effect of parvalbumin on excitotoxic motor neuron death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Ca2+-Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

alpha-Amino-3-hydroxy-5-methyl-isoxazole-4-propionate receptors in spinal cord motor neurons are altered in transgenic mice overexpressing human Cu,Zn superoxide dismutase (Gly93-->Ala) mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Role of laminin bioavailability in the astroglial permissivity for neuritic outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Na+ dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) in primary astrocyte cultures: effect of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Overexpression of Cu,Zn superoxide dismutase attenuates oxidative inhibition of astrocyte glutamate uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Nitric oxide produced by non-motoneuron cells enhances rat embryonic motoneuron sensitivity to excitotoxins: comparison in mixed neuron/glia or purified cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

Experimental destruction of substantia nigra initiated by Parkinson disease immunoglobulins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F63.9.964

21 January 2018

Identifiers

DOI

10.1093/JNEN/63.9.964

1 reference

release_rt2n57zkdncvtbp6eymhmzhssa

9 December 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rt2n57zkdncvtbp6eymhmzhssa

mapped directly with Wikidata item

24 November 2022

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