Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase (Q45016660)

8 December 2017

Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase (English)

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8 December 2017

Peter R Meyer

1

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8 December 2017

Anthony J Smith

series ordinal

2

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8 December 2017

Suzanne E Matsuura

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3

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8 December 2017

Walter A Scott

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4

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8 December 2017

language of work or name

English

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publication date

11 August 2004

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Journal of Biological Chemistry

8 December 2017

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8 December 2017

279

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8 December 2017

44

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8 December 2017

45389-45398

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Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

8 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

ATP-dependent removal of nucleoside reverse transcriptase inhibitors by human immunodeficiency virus type 1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Multidrug-resistant HIV-1 reverse transcriptase: involvement of ribonucleotide-dependent phosphorolysis in cross-resistance to nucleoside analogue inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Effects of dipeptide insertions between codons 69 and 70 of human immunodeficiency virus type 1 reverse transcriptase on primer unblocking, deoxynucleoside triphosphate inhibition, and DNA chain elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Relationship between 3′-Azido-3′-Deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-Resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Site-specific incorporation of nucleoside analogs by HIV-1 reverse transcriptase and the template grip mutant P157S. Template interactions influence substrate recognition at the polymerase active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

The emergence of different resistance mechanisms toward nucleoside inhibitors is explained by the properties of the wild type HIV-1 reverse transcriptase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

The M184V mutation reduces the selective excision of zidovudine 5'-monophosphate (AZTMP) by the reverse transcriptase of human immunodeficiency virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

HIV-1 reverse transcriptase purified from a recombinant strain of Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Interaction of fluorescently labeled dideoxynucleotides with HIV-1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Kinetic analysis of pausing and fidelity of human immunodeficiency virus type 1 reverse transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

The motif D loop of human immunodeficiency virus type 1 reverse transcriptase is critical for nucleoside 5'-triphosphate selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

A model for the mechanism of polymerase translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

NTP concentration effects on initial transcription by T7 RNAP indicate that translocation occurs through passive sliding and reveal that divergent promoters have distinct NTP concentration requirements for productive initiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Trapping HIV-1 reverse transcriptase before and after translocation on DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Protein-nucleic acid interactions and DNA conformation in a complex of human immunodeficiency virus type 1 reverse transcriptase with a double-stranded DNA template-primer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Mutations proximal to the minor groove-binding track of human immunodeficiency virus type 1 reverse transcriptase differentially affect utilization of RNA versus DNA as template

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

Protein-DNA interactions: amino acid conservation and the effects of mutations on binding specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405072200

21 January 2018

Identifiers

DOI

10.1074/JBC.M405072200

1 reference

8 December 2017

1 reference