Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial (Q44994661)

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English	Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial	scientific article

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scholarly article

1 reference

Europe PubMed Central

8 December 2017

Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial (English)

1 reference

Europe PubMed Central

8 December 2017

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object named as

John McMurray

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Frank Ruschitzka

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object named as

Frank Ruschitzka

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Europe PubMed Central

8 December 2017

Thomas Lüscher

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object named as

Thomas F Lüscher

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Europe PubMed Central

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3

object named as

Jay N Cohn

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Europe PubMed Central

8 December 2017

author name string

Inder Anand

1

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Europe PubMed Central

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Marvin A Konstam

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Europe PubMed Central

8 December 2017

Thomas Notter

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Europe PubMed Central

8 December 2017

Kurt Quitzau

6

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Europe PubMed Central

8 December 2017

EARTH investigators

9

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Europe PubMed Central

8 December 2017

language of work or name

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publication date

1 July 2004

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Europe PubMed Central

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Europe PubMed Central

8 December 2017

364

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Europe PubMed Central

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347-354

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Europe PubMed Central

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9431

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Europe PubMed Central

8 December 2017

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

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https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

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Contribution of endogenous generation of endothelin-1 to basal vascular tone

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https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

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Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels.

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https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

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Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ETA and ETB receptor blockade

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https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

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Endothelium-dependent modulation of responses to endothelin-I in human veins

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https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

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Human pulmonary circulation is an important site for both clearance and production of endothelin-1

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Elevated endothelin-1 in heart failure and loss of normal response to postural change

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Plasma endothelin in chronic heart failure

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Plasma endothelin determination as a prognostic indicator of 1-year mortality after acute myocardial infarction

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7 January 2021

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Inhibition of myocardial endothelin pathway improves long-term survival in heart failure

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https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

based on heuristic

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Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure.

1 reference

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7 January 2021

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Short-term oral endothelin-receptor antagonist therapy in conventionally treated patients with symptomatic severe chronic heart failure.

1 reference

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7 January 2021

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Clinical trials update: highlights of the scientific sessions of The American College of Cardiology 2002: LIFE, DANAMI 2, MADIT-2, MIRACLE-ICD, OVERTURE, OCTAVE, ENABLE 1 & 2, CHRISTMAS, AFFIRM, RACE, WIZARD, AZACS, REMATCH, BNP trial and HARDBALL.

1 reference

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7 January 2021

based on heuristic

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Comparison of the effects of selective endothelin ETA and ETB receptor antagonists in congestive heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

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EARTH: Endothelin A Receptor Antagonist Trial in Heart Failure

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

based on heuristic

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Proposal for a new clinical end point to evaluate the efficacy of drugs and devices in the treatment of chronic heart failure

1 reference

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7 January 2021

based on heuristic

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Noninvasive assessment of left ventricular remodeling: concepts, techniques, and implications for clinical trials

1 reference

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7 January 2021

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Application of cine nuclear magnetic resonance imaging for sequential evaluation of response to angiotensin-converting enzyme inhibitor therapy in dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

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Effect of exercise training on myocardial remodeling in patients with reduced left ventricular function after myocardial infarction: application of magnetic resonance imaging

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

based on heuristic

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Relation of ventricular size and function to heart failure status and ventricular dysrhythmia in patients with severe left ventricular dysfunction.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

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Expression of endothelin-1 and endothelin-converting enzyme-1 mRNAs and proteins in failing human hearts

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

based on heuristic

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Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure. Marked increase in endothelin-1 production in the failing heart

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

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Acute hemodynamic and neurohumoral effects of selective ET(A) receptor blockade in patients with congestive heart failure. ET 003 Investigators

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

based on heuristic

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Hemodynamic and neurohumoral effects of selective endothelin A (ET(A)) receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade Trial (HEAT).

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

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Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

based on heuristic

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A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

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Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

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Angiotensin II increases tissue endothelin and induces vascular hypertrophy: reversal by ET(A)-receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

based on heuristic

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Clinical trials update: highlights of the scientific sessions of the XXIII Congress of the European Society of Cardiology--WARIS II, ESCAMI, PAFAC, RITZ-1 and TIME

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2804%2916723-8

7 January 2021

based on heuristic

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Endothelin receptor antagonism in patients with chronic heart failure

1 reference

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7 January 2021

based on heuristic

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Contrasting inotropic effects of endogenous endothelin in the normal and failing human heart: studies with an intracoronary ET(A) receptor antagonist

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Surrogate end points in heart failure

1 reference

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7 January 2021

based on heuristic

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Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling

1 reference

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7 January 2021

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Ventricular remodeling in heart failure: a credible surrogate endpoint

1 reference

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7 January 2021

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Identifiers

10.1016/S0140-6736(04)16723-8

1 reference

Europe PubMed Central

8 December 2017

1 reference

Europe PubMed Central

8 December 2017

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