Drug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes: effects of reference compounds (Q44945058)

7 December 2017

Drug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes: effects of reference compounds (English)

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7 December 2017

Herbert M Himmel

1

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7 December 2017

20 May 2013

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Journal of Pharmacological and Toxicological Methods

7 December 2017

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7 December 2017

68

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7 December 2017

1

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7 December 2017

97-111

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Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment

7 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2013.05.005

Gender differences in the slow delayed (IKs) but not in inward (IK1) rectifier K+ currents of canine Purkinje fibre cardiac action potential: key roles for IKs, beta-adrenoceptor stimulation, pacing rate and gender.

7 January 2021

1 reference

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Electrophysiological and inotropic effects of H 234/09 (almokalant) in vitro: a comparison with two other novel IK blocking drugs, UK-68,798 (dofetilide) and E-4031

7 January 2021

1 reference

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Afterload reduction: a comparison of captopril and nifedipine in dilated cardiomyopathy

7 January 2021

1 reference

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Tetrodotoxin-sensitive component in action potential plateau of guinea pig Purkinje fibers: comparison with the papillary muscle

7 January 2021

1 reference

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Voltage-dependent action of tetrodotoxin in mammalian cardiac muscle

7 January 2021

1 reference

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Effects of New and Potent Methanesulfonanilide Class III Antiarrhythmic Agents on Myocardial Refractoriness and Contractility in Isolated Cardiac Muscle

7 January 2021

1 reference

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Effects of the chromanol HMR 1556 on potassium currents in atrial myocytes

7 January 2021

1 reference

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Regulation of unloaded cell shortening by sarcolemmal sodium-calcium exchange in isolated rat ventricular myocytes.

7 January 2021

1 reference

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Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes

7 January 2021

1 reference

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Voltage-dependent block by tetrodotoxin of the sodium channel in rabbit cardiac Purkinje fibers

7 January 2021

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Sea anemone toxin (ATX II) modulation of heart and skeletal muscle sodium channel alpha-subunits expressed in tsA201 cells

7 January 2021

1 reference

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Assessment of two external telemetry systems (PhysioJacket and JET) in beagle dogs with telemetry implants.

7 January 2021

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Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations

7 January 2021

1 reference

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Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating

7 January 2021

1 reference

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Pentamidine reduces hERG expression to prolong the QT interval

7 January 2021

1 reference

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Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.

7 January 2021

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Molecular determinants of pentamidine-induced hERG trafficking inhibition

7 January 2021

1 reference

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The effects of lignocaine and tetrodotoxin on the action potentials and contractions of left ventricles from normo- and hypertensive rats.

7 January 2021

1 reference

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High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology

7 January 2021

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Electrophysiologic effects of dextro- and levo-verapamil on sinus node and AV node function in humans

7 January 2021

1 reference

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The impact of drug-induced QT interval prolongation on drug discovery and development

7 January 2021

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Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition

7 January 2021

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Inhibition of IKs channels by HMR 1556.

7 January 2021

1 reference

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Induced pluripotent stem cells--opportunities for disease modelling and drug discovery

7 January 2021

1 reference

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Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes

7 January 2021

1 reference

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The electrophysiological effects of cardiac glycosides in human iPSC-derived cardiomyocytes and in guinea pig isolated hearts

7 January 2021

1 reference

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Preparation, preparation, preparation: The influence of adrenergic agonism in cardiac ventricular repolarisation assays used in preclinical drug development and drug safety pharmacology

7 January 2021

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Development of a drug screening platform based on engineered heart tissue

7 January 2021

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The human embryonic stem cell-derived cardiomyocyte as a pharmacological model

7 January 2021

1 reference

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Validation of an in vitro contractility assay using canine ventricular myocytes

7 January 2021

1 reference

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The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity

7 January 2021

1 reference

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Suitability of commonly used excipients for electrophysiological in-vitro safety pharmacology assessment of effects on hERG potassium current and on rabbit Purkinje fiber action potential

7 January 2021

1 reference

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Field and action potential recordings in heart slices: correlation with established in vitro and in vivo models.

7 January 2021

1 reference

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Effects of the Anemonia sulcata toxin (ATX II) on intracellular sodium and contractility in rat and guinea-pig myocardium

7 January 2021

1 reference

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The effects of the Anemonia sulcata toxin (ATX II) on membrane currents of isolated mammalian myocytes

7 January 2021

1 reference

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Tetrodotoxin slightly shortens action potential duration in ventricular but not in atrial heart muscle

7 January 2021

1 reference

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Drug-induced effects on cardiovascular function in pentobarbital anesthetized guinea-pigs: invasive LVP measurements versus the QA interval.

7 January 2021

1 reference

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Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.

7 January 2021

1 reference

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Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived cardiomyocytes

7 January 2021

1 reference

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Tetrodotoxin-sensitive inactivation-resistant sodium channels in pacemaker cells influence heart rate.

7 January 2021

1 reference

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Ca²⁺ channel activators reveal differential L-type Ca²⁺ channel pharmacology between native and stem cell-derived cardiomyocytes

7 January 2021

1 reference

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Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.

7 January 2021

1 reference

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Electrophysiological effects of E 4031, a drug with selective class III properties, in man

7 January 2021

1 reference

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Stem cells and their derivatives: a renaissance in cardiovascular translational research

7 January 2021

1 reference

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Rate and concentration-dependent effects of UK-68,798, a potent new class III antiarrhythmic, on canine Purkinje fibre action potential duration and Vmax

7 January 2021

1 reference

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Pentamidine-induced long QT syndrome and block of hERG trafficking

7 January 2021

1 reference

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In vitro models of proarrhythmia

7 January 2021

1 reference

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Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes

7 January 2021

1 reference

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Both beta-adrenergic receptor stimulation and cardiac tissue type have important roles in elucidating the functional effects of I(Ks) channel blockers in vitro

7 January 2021

1 reference

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Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review.

7 January 2021

1 reference

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Comparison of Ca2+ channel inhibitory effects of cibenzoline with verapamil on guinea-pig heart.

7 January 2021

1 reference

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Cardiotoxicity associated with targeting kinase pathways in cancer

7 January 2021

1 reference

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Kinetics and state-dependent effects of verapamil on cardiac L-type calcium channels.

7 January 2021

1 reference

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The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes

7 January 2021

1 reference

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Embryonic stem cells as a source of models for drug discovery.

7 January 2021

1 reference

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BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heart.

7 January 2021

1 reference

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

7 January 2021

1 reference

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Effect of cardioactive drugs on action potential generation and propagation in embryonic stem cell-derived cardiomyocytes.

7 January 2021

1 reference

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Attenuation of the negative inotropic effects of metoprolol at short cycle lengths in humans: comparison with sotalol and verapamil

7 January 2021

1 reference

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Drug-induced prolongation of the QT interval

7 January 2021

1 reference

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Cardiac and hemodynamic effects of intravenous dofetilide in patients with heart failure

7 January 2021

1 reference

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Inotropic agents in the treatment of heart failure: despair or hope?

7 January 2021

1 reference

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A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties

7 January 2021

1 reference

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Introduction of a modular automated voltage-clamp platform and its correlation with manual human Ether-à-go-go related gene voltage-clamp data

7 January 2021

1 reference

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Negative inotropic properties of isradipine, nifedipine, diltiazem, and verapamil in diseased human myocardial tissue

7 January 2021

1 reference

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Effects of inhibition of calcium and potassium currents in guinea-pig cardiac contraction: comparison of beta-caryophyllene oxide, eugenol, and nifedipine

7 January 2021

1 reference

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Drugs, QT interval prolongation and ICH E14: the need to get it right

7 January 2021

1 reference

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Blockade of IKs by HMR 1556 increases the reverse rate-dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles

7 January 2021

1 reference

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Intrinsic and reflex actions of verapamil and nifedipine: assessment in normal subjects by noninvasive techniques and autonomic blockade.

7 January 2021

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Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue

7 January 2021

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Myocardial and vascular effects of efonidipine in vitro as compared with nifedipine, verapamil and diltiazem

7 January 2021

1 reference

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Rate-dependent class III antiarrhythmic action, negative chronotropy, and positive inotropy of a novel Ik blocking drug, UK-68,798: potent in guinea pig but no effect in rat myocardium

7 January 2021

1 reference

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Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells

7 January 2021

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Stoichiometry of the slow I(ks) potassium channel in human embryonic stem cell-derived myocytes

7 January 2021

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Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog.

7 January 2021

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Comparison of contractile behavior of native murine ventricular tissue and cardiomyocytes derived from embryonic or induced pluripotent stem cells.

7 January 2021

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Functional cardiotoxicity profiling and screening using the xCELLigence RTCA Cardio System

7 January 2021

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A novel method of selecting human embryonic stem cell-derived cardiomyocyte clusters for assessment of potential to influence QT interval

7 January 2021

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Effects of acute intravenous administration of pentamidine, a typical hERG-trafficking inhibitor, on the cardiac repolarization process of halothane-anesthetized dogs

7 January 2021

1 reference

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Dofetilide enhances the contractility of rat ventricular myocytes via augmentation of Na+-Ca 2+ exchange

7 January 2021

1 reference

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Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

7 January 2021

1 reference

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10.1016/J.VASCN.2013.05.005

7 January 2021

Identifiers

DOI

1 reference

release_5utt56726fdupbia4xdnn62jwq

7 December 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5utt56726fdupbia4xdnn62jwq

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

23702537

1 reference

PubMed ID

23702537