BRCA1 185delAG truncation protein, BRAt, amplifies caspase-mediated apoptosis in ovarian cells (Q44934254)

7 December 2017

BRCA1 185delAG truncation protein, BRAt, amplifies caspase-mediated apoptosis in ovarian cells (English)

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7 December 2017

Joshua D O'Donnell

1

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7 December 2017

Nicole C Johnson

2

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7 December 2017

Tracy D Turbeville

3

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7 December 2017

Michelle Y Alfonso

4

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7 December 2017

Patricia A Kruk

5

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7 December 2017

2 July 2008

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In Vitro Cellular & Developmental Biology - Animal

7 December 2017

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7 December 2017

44

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7 December 2017

8-9

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7 December 2017

357-367

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https://scigraph.springernature.com/pub.10.1007/s11626-008-9122-0

7 December 2017

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AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

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https://api.crossref.org/works/10.1007%2FS11626-008-9122-0

The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals

21 January 2018

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The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codons

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Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1

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Dominant-negative activity of a Brca1 truncation mutant: effects on proliferation, tumorigenicity in vivo, and chemosensitivity in a mouse ovarian cancer cell line.

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12 December 2020

Identification of the 185delAG BRCA1 mutation in a Spanish Gypsy population

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Cell proliferation and apoptosis in BRCA-associated hereditary ovarian cancer

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Cytology of human ovarian surface epithelial brushings.

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BRCA1 splice variants exhibit overlapping and distinct transcriptional transactivation activities

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Hereditary and sporadic ovarian cancer: genetic testing and clinical implications (review).

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The IAP family: endogenous caspase inhibitors with multiple biological activities

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Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

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Distinct transcription start sites generate two forms of BRCA1 mRNA.

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12 December 2020

BRCA1 Facilitates Stress-induced Apoptosis in Breast and Ovarian Cancer Cell Lines

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12 December 2020

Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice

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12 December 2020

Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation.

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Targeting Akt in cancer therapy

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Cancer statistics, 2006

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Human, canine and murine BRCA1 genes: sequence comparison among species.

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The nonsense-mediated decay RNA surveillance pathway

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Characterization of cultured human ovarian surface epithelial cells: phenotypic plasticity and premalignant changes.

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Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells

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Induction of apoptosis by the tumor suppressor protein BRCA1.

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Ultraviolet irradiation- and dimethyl sulfoxide-induced telomerase activity in ovarian epithelial cell lines

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Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

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12 December 2020

Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant

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12 December 2020

BRCA1 wild-type allele modifies risk of ovarian cancer in carriers of BRCA1 germ-line mutations

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The presence of plasmin receptors on three mammary carcinoma MCF-7 sublines

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A survey of telomerase activity in human cancer

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Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts

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12 December 2020

BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis

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12 December 2020

BRCA1 185delAG mutation inhibits Akt-dependent, IAP-mediated caspase 3 inactivation in human ovarian surface epithelial cells

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12 December 2020

Familial form of hirschsprung disease: nucleotide sequence studies reveal point mutations in the RET proto-oncogene in two of six families but not in other candidate genes

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12 December 2020

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

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12 December 2020

Telomeric instability and reduced proliferative potential in ovarian surface epithelial cells from women with a family history of ovarian cancer

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Clinical features of ovarian cancer in Japanese women with germ-line mutations of BRCA1

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Acute chemotherapy-related toxicity is not increased in BRCA1 and BRCA2 mutation carriers treated for breast cancer in the United Kingdom

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Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families

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BRCA1 Zinc RING Finger Domain Disruption Alters Caspase Response in Ovarian Surface Epithelial Cells

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12 December 2020

Identification of germline 185delAG BRCA1 mutations in non-Jewish Americans of Spanish ancestry from the San Luis Valley, Colorado

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12 December 2020

Emerging roles of BRCA1 alternative splicing

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[Familial ovarian carcinoma]

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12 December 2020

BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells

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12 December 2020

Cancer statistics, 2007

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Targeting the AKT protein kinase for cancer chemoprevention

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Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium

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12 December 2020

10.1007/S11626-008-9122-0

Identifiers

DOI

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7 December 2017

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