Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic (Q44819303)

6 December 2017

Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic (English)

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6 December 2017

2

Dirk Grimm

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6 December 2017

Jeffery C Giering

1

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PubMed ID

18665161

6 December 2017

Theresa A Storm

series ordinal

3

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PubMed ID

18665161

6 December 2017

Mark A Kay

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4

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6 December 2017

29 July 2008

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6 December 2017

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6 December 2017

16

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6 December 2017

1630-1636

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6 December 2017

9

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Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

6 December 2017

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

CRE recombinase-inducible RNA interference mediated by lentiviral vectors

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Tuning silence: conditional systems for RNA interference

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Sequence-specific inhibition of small RNA function

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Use of RNA polymerase II to transcribe artificial microRNAs.

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Vector-based RNAi approaches for stable, inducible and genome-wide screens

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Inhibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Second-generation shRNA libraries covering the mouse and human genomes

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

siRNA-mediated gene silencing in vitro and in vivo.

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

RNA interference is mediated by 21- and 22-nucleotide RNAs

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

shRNA driven by Pol II/T7 dual-promoter system effectively induce cell-specific RNA interference in mammalian cells

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

3' end formation of U1 snRNA precursors is coupled to transcription from snRNA promoters

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Formation of the 3' end of U1 snRNA requires compatible snRNA promoter elements

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

The 3' ends of human pre-snRNAs are produced by RNA polymerase II CTD-dependent RNA processing

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Gene silencing in alveolar type II cells using cell-specific promoter in vitro and in vivo

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Negative feedback inhibition of HIV-1 by TAT-inducible expression of siRNA.

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Functional siRNAs and miRNAs Exhibit Strand Bias

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Asymmetry in the assembly of the RNAi enzyme complex

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https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Poly(U) and polyadenylation termination signals are interchangeable for terminating the expression of shRNA from a pol II promoter

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.144

7 January 2021

Identifiers

DOI

10.1038/MT.2008.144

1 reference

6 December 2017

1 reference

PubMed ID

18665161