Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions (Q44792904)

6 December 2017

Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions (English)

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6 December 2017

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Jana Narasimhan

1

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6 December 2017

Kirk A Staschke

series ordinal

2

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6 December 2017

Ronald C Wek

series ordinal

3

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6 December 2017

language of work or name

English

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publication date

9 March 2004

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Journal of Biological Chemistry

6 December 2017

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6 December 2017

279

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6 December 2017

22

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6 December 2017

22820-22832

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eIF-2 kinases: regulators of general and gene-specific translation initiation

6 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

A simple method for displaying the hydropathic character of a protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

NPS@: network protein sequence analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Multiple upstream AUG codons mediate translational control of GCN4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Physical and functional characterization of the double-stranded RNA binding protein encoded by the vaccinia virus E3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

TOR modulates GCN4-dependent expression of genes turned on by nitrogen limitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

The protein kinase Gcn2p mediates sodium toxicity in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Autophagy in the eukaryotic cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Nutrient-regulated protein kinases in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

The dsRNA binding protein family: critical roles, diverse cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

The effects of NaCl on the amino acid acceptor activity of rat liver tRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Sodium transport in plant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

Transcriptional activation by Gcn4p involves independent interactions with the SWI/SNF complex and the SRB/mediator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

The Gcn4p activation domain interacts specifically in vitro with RNA polymerase II holoenzyme, TFIID, and the Adap-Gcn5p coactivator complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

The Sko1p repressor and Gcn4p activator antagonistically modulate stress-regulated transcription in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

The immunosuppressant FK506 uncovers a positive regulatory cross-talk between the Hog1p and Gcn2p pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M402228200

21 January 2018

Identifiers

DOI

10.1074/JBC.M402228200

1 reference

6 December 2017

1 reference