Toward computational identification of multiscale "tipping points" in acute inflammation and multiple organ failure (Q44774893)

6 December 2017

Toward computational identification of multiscale "tipping points" in acute inflammation and multiple organ failure (English)

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6 December 2017

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6 December 2017

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Yoram Vodovotz

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6 December 2017

Gary Nieman

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6 December 2017

21 April 2012

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Annals of Biomedical Engineering

6 December 2017

11

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based on heuristic

inferred from page(s)

published in

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6 December 2017

40

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6 December 2017

11

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6 December 2017

2414-2424

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https://scigraph.springernature.com/pub.10.1007/s10439-012-0565-9

6 December 2017

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cites work

Mechanisms of sepsis-induced organ dysfunction

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Network motifs: theory and experimental approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Challenges and rewards on the road to translational systems biology in acute illness: four case reports from interdisciplinary teams

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Fast, cheap and somewhat in control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

How we detect microbes and respond to them: the Toll-like receptors and their transducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

The community of the self

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Compartmentalization of the inflammatory response in sepsis and SIRS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Molecular biology of multiple organ dysfunction syndrome: injury, adaptation, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Injury research in the genomic era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

The Fourth National Institutes of Health Symposium on the Functional Genomics of Critical Injury: Surviving stress from organ systems to molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Reverse engineering of biological complexity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Year in review 2010: Critical Care--Multiple organ dysfunction and sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Role of the gut lymphatic system in multiple organ failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Pathways of renal injury in systemic gram-negative sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Airway pressures, tidal volumes, and mortality in patients with acute respiratory distress syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

NETWORKS, BIOLOGY AND SYSTEMS ENGINEERING: A CASE STUDY IN INFLAMMATION.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Anti-inflammatory therapies in sepsis and septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Matrix-metalloproteinase-2, -8 and -9 in serum and skin blister fluid in patients with severe sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

21 January 2018

Peritoneal resuscitation

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Focus issue: conquering the data mountain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Improvements in the reconstruction of time-varying gene regulatory networks: dynamic programming and regularization by information sharing among genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Multiple organ failure in sepsis: prognosis and role of systemic inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

The endothelium in sepsis: source of and a target for inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Effects of vasopressin on microcirculatory blood flow in the gastrointestinal tract in anesthetized pigs in septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Effects of dopamine, dobutamine, and dopexamine on microcirculatory blood flow in the gastrointestinal tract during sepsis and anesthesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

The microcirculation is the motor of sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Data-driven modelling of signal-transduction networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Effects of epinephrine, norepinephrine, and phenylephrine on microcirculatory blood flow in the gastrointestinal tract in sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

A clinically applicable porcine model of septic and ischemia/reperfusion-induced shock and multiple organ injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Preclinical models of shock and sepsis: what can they tell us?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Translational systems biology of inflammation: potential applications to personalized medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

The role of the gastrointestinal tract in postinjury multiple organ failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

The acute inflammatory response in trauma / hemorrhage and traumatic brain injury: current state and emerging prospects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Points of control in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

New approaches to shock and trauma research: learning from multidisciplinary exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Experimental models of gram-negative sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Global patterns of mortality in young people: a systematic analysis of population health data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: a novel timing-based ventilatory intervention to avert lung injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Hypothesis: compartmentalization of cytokines in intraabdominal infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Bacterial translocation: what it is and what it is not.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

The development of acute respiratory distress syndrome after gut ischemia/reperfusion injury followed by fecal peritonitis in pigs: a clinically relevant model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

The gut in systemic inflammatory response syndrome and sepsis. Enzyme systems fighting multiple organ failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Sepsis research in the next millennium: concentrate on the software rather than the hardware

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Mathematical modeling of posthemorrhage inflammation in mice: studies using a novel, computer-controlled, closed-loop hemorrhage apparatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Reflex control of immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Translational systems biology of inflammation and healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

In silico models of acute inflammation in animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Mathematical models of the acute inflammatory response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Mechanistic simulations of inflammation: current state and future prospects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Chemotaxis in Escherichia coli: a molecular model for robust precise adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Postresuscitation tissue neutrophil infiltration is time-dependent and organ-specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Mechanisms of direct peritoneal resuscitation-mediated splanchnic hyperperfusion following hemorrhagic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

Cellular edema regulates tissue capillary perfusion after hemorrhage resuscitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

The search for effective therapy for sepsis: back to the drawing board?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10439-012-0565-9

10.1007/S10439-012-0565-9

21 January 2018

Identifiers

DOI

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6 December 2017

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PubMed ID

22527009