Gbetagamma subunits stimulate p21-activated kinase 1 (PAK1) through activation of PI3-kinase and Akt but act independently of Rac1/Cdc42. (Q44714820)

5 December 2017

Gbetagamma subunits stimulate p21-activated kinase 1 (PAK1) through activation of PI3-kinase and Akt but act independently of Rac1/Cdc42. (English)

1 reference

5 December 2017

Raymond E Menard

1

1 reference

PubMed ID

14706848

5 December 2017

Raymond R Mattingly

series ordinal

2

1 reference

PubMed ID

14706848

5 December 2017

language of work or name

English

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publication date

1 January 2004

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5 December 2017

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5 December 2017

556

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5 December 2017

1-3

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5 December 2017

187-192

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Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

5 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Phosphoinositide 3-kinases: a conserved family of signal transducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Synthesis and function of 3-phosphorylated inositol lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Role of translocation in the activation and function of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

21 January 2018

1 reference

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Generation of reactive oxygen species by human mesothelioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

High RhoA activity maintains the undifferentiated mesenchymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

The p21Rac/Cdc42-activated kinases (PAKs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Flipping the switch: the structural basis for signaling through the CRIB motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Structural requirements for PAK activation by Rac GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Down-regulation of growth factor-stimulated MAP kinase signaling in cytotoxic drug-resistant human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Potent suppression of proliferation of a10 vascular smooth muscle cells by combined treatment with lovastatin and 3-allylfarnesol, an inhibitor of protein farnesyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Necessary role of phosphatidylinositol 3-kinase in transforming growth factor beta-mediated activation of Akt in normal and rheumatoid arthritis synovial fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Phosphatidylinositol 3-kinases in tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Phosphatidylinositol 3-kinase activity is required for the expression of glial fibrillary acidic protein upon cAMP-dependent induction of differentiation in rat C6 glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Association of phosphatidylinositol 3-kinase composed of p110beta-catalytic and p85-regulatory subunits with the small GTPase Rab5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

G protein specificity: traffic direction required.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Unravelling the activation mechanisms of protein kinase B/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

The Akt proto-oncogene links Ras to Pak and cell survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Association of PI-3 kinase with PAK1 leads to actin phosphorylation and cytoskeletal reorganization

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Direct or C5a-induced activation of heterotrimeric Gi2 proteins in human neutrophils is associated with interaction between formyl peptide receptors and the cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Roles of PAK family kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Reciprocal Signaling between Heterotrimeric G Proteins and the p21-stimulated Protein Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Mechanism of activation of protein kinase B by insulin and IGF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Phosphoinositide 3-kinases in lysophosphatidic acid signaling: regulation and cross-talk with the Ras/mitogen-activated protein kinase pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

7 January 2021

Rac and Cdc42 effectors

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2901406-6

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0014-5793(03)01406-6

1 reference

5 December 2017

1 reference

PubMed ID

14706848