A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src. (Q44558581)

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7 November 2019

title

A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src (English)

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7 November 2019

1

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7 November 2019

Mike-Andrew Westhoff

2

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7 November 2019

author name string

Valerie J Fincham

3

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7 November 2019

Michael D Schaller

4

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7 November 2019

Margaret C Frame

5

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7 November 2019

language of work or name

English

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publication date

1 August 2003

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7 November 2019

number of pages

9

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inferred from page(s)

published in

Current Biology

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7 November 2019

volume

13

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7 November 2019

page(s)

1442-1450

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7 November 2019

issue

16

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

7 November 2019

cites work

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7 January 2021

Src family kinases are required for integrin but not PDGFR signal transduction.

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Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway

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7 January 2021

Cutting to the chase: calpain proteases in cell motility

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7 January 2021

Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion

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7 January 2021

Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain

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7 January 2021

Calpain regulation of cytoskeletal signaling complexes in von Willebrand factor-stimulated platelets. Distinct roles for glycoprotein Ib-V-IX and glycoprotein IIb-IIIa (integrin alphaIIbbeta3) in von Willebrand factor-induced signal transduction

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7 January 2021

Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talin

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7 January 2021

Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases.

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7 January 2021

Evidence for involvement of calpain in c-Myc proteolysis in vivo.

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Rigidity of collagen fibrils controls collagen gel-induced down-regulation of focal adhesion complex proteins mediated by alpha2beta1 integrin.

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7 January 2021

Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts

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7 January 2021

v-Src-induced modulation of the calpain-calpastatin proteolytic system regulates transformation.

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7 January 2021

SH2- and SH3-mediated interactions between focal adhesion kinase and Src.

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7 January 2021

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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7 January 2021

Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides

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7 January 2021

Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src

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7 January 2021

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

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7 January 2021

Investigation of the interaction of m-calpain with phospholipids: calpain-phospholipid interactions

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7 January 2021

Role of phospholipids in the activation of the Ca2+-dependent neutral proteinase of human erythrocytes

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7 January 2021

Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling.

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7 January 2021

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12932330%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

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