Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein (Q44543802)

4 December 2017

Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein (English)

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4 December 2017

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multiple drug resistance

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1

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4 December 2017

M Claire Bartlett

2

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PubMed ID

12909621

4 December 2017

David M Clarke

series ordinal

3

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PubMed ID

12909621

4 December 2017

language of work or name

English

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publication date

7 August 2003

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Journal of Biological Chemistry

4 December 2017

5

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based on heuristic

inferred from page(s)

published in

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4 December 2017

278

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4 December 2017

39706-39710

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4 December 2017

41

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

4 December 2017

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

Multidrug resistance in cancer: role of ATP-dependent transporters

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

The human ATP-binding cassette (ABC) transporter superfamily

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

Membrane topology of a cysteine-less mutant of human P-glycoprotein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

The minimum functional unit of human P-glycoprotein appears to be a monomer.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Permanent Activation of the Human P-glycoprotein by Covalent Modification of a Residue in the Drug-binding Site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

P-glycoprotein. Associations between domains and between domains and molecular chaperones

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Quality control by proteases in the endoplasmic reticulum. Removal of a protease-sensitive site enhances expression of human P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Novel sulfhydryl reagents

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

Structural changes in the calcium pump accompanying the dissociation of calcium

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

Structural mechanisms of QacR induction and multidrug recognition

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M308559200

Extraction of Hoechst 33342 from the cytoplasmic leaflet of the plasma membrane by P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Competitive and non-competitive inhibition of the multidrug-resistance-associated P-glycoprotein ATPase--further experimental evidence for a multisite model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

21 January 2018

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Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308559200

Membrane topology of P-glycoprotein as determined by epitope insertion: transmembrane organization of the N-terminal domain of mdr3

21 January 2018

1 reference

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ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

21 January 2018

1 reference

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A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M308559200

1 reference

4 December 2017

1 reference

PubMed ID

12909621