Regional transport and metabolism of ropivacaine and its CYP3A4 metabolite PPX in human intestine (Q44541631)

4 December 2017

title

Regional transport and metabolism of ropivacaine and its CYP3A4 metabolite PPX in human intestine (English)

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4 December 2017

Sofia Berggren

1

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4 December 2017

Pernilla Lennernäs

2

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4 December 2017

Mats Ekelund

3

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4 December 2017

Björn Weström

4

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4 December 2017

Janet Hoogstraate

5

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4 December 2017

Hans Lennernäs

6

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4 December 2017

publication date

1 July 2003

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Journal of Pharmacy and Pharmacology

4 December 2017

published in

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4 December 2017

volume

55

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4 December 2017

issue

7

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4 December 2017

page(s)

963-972

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P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels.

4 December 2017

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Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: an interaction study with fluvoxamine and ketoconazole as in vivo inhibitors.

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Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate

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21 January 2018

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The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil.

21 January 2018

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21 January 2018

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Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells

21 January 2018

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Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates

21 January 2018

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Lipid permeability of the intestinal microvillus membrane may be modulated by membrane fluidity in the rat.

21 January 2018

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Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas.

21 January 2018

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Pharmacokinetics of felodipine in patients with liver disease

21 January 2018

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Integrity and metabolism of human ileal mucosa in vitro in the Ussing chamber

21 January 2018

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Grapefruit juice activates P-glycoprotein-mediated drug transport

21 January 2018

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Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

21 January 2018

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Membrane transport of drugs in different regions of the intestinal tract of the rat.

21 January 2018

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Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

21 January 2018

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Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.

21 January 2018

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High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy

21 January 2018

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Jejunal permeability: a comparison between the ussing chamber technique and the single-pass perfusion in humans

21 January 2018

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Intestinal permeability in humans is increased after radiation therapy

21 January 2018

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Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs

21 January 2018

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The barrier function of CYP3A4 and P-glycoprotein in the small bowel

21 January 2018

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21 January 2018

Identifiers

DOI

10.1211/0022357021495

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4 December 2017

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