Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications (Q44511146)

3 December 2017

Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications (English)

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3 December 2017

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Erin H Norris

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3 December 2017

Benoit I Giasson

series ordinal

2

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3 December 2017

Harry Ischiropoulos

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3

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3 December 2017

Virginia M-Y Lee

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4

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3 December 2017

language of work or name

English

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publication date

8 May 2003

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Journal of Biological Chemistry

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11

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based on heuristic

inferred from page(s)

published in

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3 December 2017

278

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3 December 2017

29

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3 December 2017

27230-27240

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The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

3 December 2017

1 reference

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Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Identification of two distinct synucleins from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Intraneuronal filamentous tau protein and alpha-synuclein deposits in neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Neuropathology of synuclein aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Widespread alterations of alpha-synuclein in multiple system atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Synergistic interactions between NADPH-cytochrome P-450 reductase, paraquat, and iron in the generation of active oxygen radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Diazeniumdiolates: pro- and antioxidant applications of the "NONOates".

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Methionine oxidation inhibits fibrillation of human alpha-synuclein in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212436200

21 January 2018

Identifiers

DOI

10.1074/JBC.M212436200

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3 December 2017

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