Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling (Q44488090)

3 December 2017

Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling (English)

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3 December 2017

Zhiming Suo

1

1 reference

3 December 2017

Min Wu

2

1 reference

3 December 2017

Bruce A Citron

3

1 reference

3 December 2017

Robert E Palazzo

4

1 reference

3 December 2017

Barry W Festoff

5

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3 December 2017

language of work or name

English

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publication date

23 June 2003

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Journal of Biological Chemistry

3 December 2017

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3 December 2017

278

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3 December 2017

37681-37689

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3 December 2017

39

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Neurodegenerative tauopathies

3 December 2017

1 reference

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Are pathological lesions in neurodegenerative disorders the cause or the effect of the degeneration?

21 January 2018

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Tau protein pathology in neurodegenerative diseases.

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5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10.

21 January 2018

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Morphometric comparison of hippocampal microvasculature in ageing and demented people: Diameters and densities

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Brain microvascular changes in Alzheimer's disease and other dementias.

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Alzheimer disease as a vascular disorder: nosological evidence

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Alzheimer disease and cerebrovascular pathology: an update

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Traumatic brain injury as a risk factor for Alzheimer's disease: a review.

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Neuronal cytoskeletal changes are an early consequence of repetitive head injury

21 January 2018

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Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig.

21 January 2018

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Emergence of immunoreactivities for phosphorylated tau and amyloid-beta protein in chronic stage of fluid percussion injury in rat brain.

21 January 2018

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Thrombin signalling and protease-activated receptors

21 January 2018

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Thrombin Stimulation of Guanosine 3′,5′-Monophosphate Formation in Murine Neuroblastoma Cells (Clone N1E-115)

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Alterations in serum thrombospondin in patients with amyotrophic lateral sclerosis

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Serine proteases and their serpin inhibitors in Alzheimer's disease

21 January 2018

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Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture.

21 January 2018

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Participation of protease-activated receptor-1 in thrombin-induced microglial activation

21 January 2018

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Thrombin induced inhibition of neurite outgrowth from dorsal root ganglion neurons.

21 January 2018

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Inflammatory response in Alzheimer's disease

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Thrombin accumulation in brains of patients with Alzheimer's disease

21 January 2018

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Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease

21 January 2018

1 reference

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Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease

21 January 2018

1 reference

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A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.

21 January 2018

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Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death.

21 January 2018

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The regulation of reactive oxygen species production during programmed cell death

21 January 2018

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Superoxide free radical and intracellular calcium mediate A beta(1-42) induced endothelial toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Co-localization of truncated tau and DNA fragmentation in Alzheimer's disease neurones.

21 January 2018

1 reference

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Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

21 January 2018

1 reference

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

21 January 2018

1 reference

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Role of High-Affinity Thrombin Receptors in Postclotting Cellular Effects of Thrombin

21 January 2018

1 reference

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cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization.

21 January 2018

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Protease-activated receptor 3 is a second thrombin receptor in humans

21 January 2018

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Cloning and characterization of human protease-activated receptor 4

21 January 2018

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A dual thrombin receptor system for platelet activation

21 January 2018

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Molecular cloning of a potential proteinase activated receptor

21 January 2018

1 reference

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Interactions of mast cell tryptase with thrombin receptors and PAR-2.

21 January 2018

1 reference

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Role of thrombin signalling in platelets in haemostasis and thrombosis

21 January 2018

1 reference

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Possible role of tau protein kinases in pathogenesis of Alzheimer's disease.

21 January 2018

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The molecular bases of Alzheimer's disease and other neurodegenerative disorders

21 January 2018

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The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

21 January 2018

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Tau protein phosphorylation as a therapeutic target in Alzheimer's disease

21 January 2018

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Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells.

21 January 2018

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Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.

21 January 2018

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Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry

21 January 2018

1 reference

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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

21 January 2018

1 reference

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Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein

21 January 2018

1 reference

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Evidence for synaptic apoptosis.

21 January 2018

1 reference

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Immunolocalization of caspase proteolysis in situ: evidence for widespread caspase-mediated apoptosis of neurons and glia in the postnatal rat brain

21 January 2018

1 reference

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Thrombin induces IL-10 production in microglia as a negative feedback regulator of TNF-alpha release.

21 January 2018

1 reference

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Thrombin modulates and reverses neuroblastoma neurite outgrowth

21 January 2018

1 reference

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Calcium mobilization and protease-activated receptor cleavage after thrombin stimulation in motor neurons

21 January 2018

1 reference

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Effect of proteases and their inhibitors on neurite outgrowth from neonatal mouse sensory ganglia in culture.

21 January 2018

1 reference

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Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

21 January 2018

1 reference

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Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model

21 January 2018

1 reference

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The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Thrombin, its receptor and protease nexin I, its potent serpin, in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Thrombin interactions with central nervous system tissue and implications of these interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Thrombin-induced reversal of astrocyte stellation is mediated by activation of protein kinase C beta-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Thrombin-induced activation of cultured rodent microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

The cytoskeleton in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Role of specific cell surface receptors in thrombin-stimulated cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Acceleration of soft tissue repair by a thrombin-derived oligopeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

The neurite retraction induced by lysophosphatidic acid increases Alzheimer's disease-like Tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Exogenous thrombin inhibits neuritogenesis in cultured neuroblastoma cells but not in rat hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

Modelling Alzheimer's disease in multiple transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301406200

21 January 2018

Identifiers

DOI

10.1074/JBC.M301406200

1 reference

3 December 2017

1 reference