Inducible p27(Kip1) expression inhibits proliferation of K562 cells and protects against apoptosis induction by proteasome inhibitors (Q44407032)

2 December 2017

Inducible p27(Kip1) expression inhibits proliferation of K562 cells and protects against apoptosis induction by proteasome inhibitors (English)

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2 December 2017

H C A Drexler

1

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PubMed ID

12700629

2 December 2017

S Pebler

series ordinal

2

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2 December 2017

1 March 2003

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Cell Death & Differentiation

2 December 2017

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2 December 2017

10

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2 December 2017

290-301

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2 December 2017

3

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401159

2 December 2017

0 references

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

1 reference

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Activation of the cell death program by inhibition of proteasome function

21 January 2018

1 reference

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Suppression of actinomycin D-induced apoptosis by the NS3 protein of hepatitis C virus

21 January 2018

1 reference

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Apoptosis induction resulting from proteasome inhibition

21 January 2018

1 reference

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Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts

21 January 2018

1 reference

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p53-dependent cell cycle arrest induced by N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal in platelet-derived growth factor-stimulated human fibroblasts

21 January 2018

1 reference

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Proteasome-dependent regulation of p21WAF1/CIP1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

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Proteasome inhibitors: from research tools to drug candidates

21 January 2018

1 reference

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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

Transcriptional up-regulation of p27(Kip1) during contact-induced growth arrest in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway

21 January 2018

1 reference

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BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway

21 January 2018

1 reference

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Dominant negative MYC blocks transformation by ABL oncogenes

21 January 2018

1 reference

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Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

21 January 2018

1 reference

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p53-mediated downregulation of Chk1 abrogates the DNA damage-induced G2M checkpoint in K562 cells, resulting in increased apoptosis

21 January 2018

1 reference

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p53 expression in K562 cells is associated with caspase-mediated cleavage of c-ABL and BCR-ABL protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

BAD induces apoptosis in cells over-expressing Bcl-2 or Bcl-xL without loss of mitochondrial membrane potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

21 January 2018

1 reference

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Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

21 January 2018

1 reference

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Induction of apoptosis in fibroblasts by c-myc protein

21 January 2018

1 reference

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Proteasome inhibitors induce Fas-mediated apoptosis by c-Myc accumulation and subsequent induction of FasL message in human glioma cells

21 January 2018

1 reference

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Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

21 January 2018

1 reference

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Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

21 January 2018

1 reference

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

21 January 2018

1 reference

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Proteasome inhibitors induced caspase-dependent apoptosis and accumulation of p21WAF1/Cip1 in human immature leukemic cells.

21 January 2018

1 reference

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The apoptogenic response of human myeloid leukaemia cell lines and of normal and malignant haematopoietic progenitor cells to the proteasome inhibitor PSI.

21 January 2018

1 reference

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Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

21 January 2018

1 reference

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Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

21 January 2018

1 reference

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 January 2018

1 reference

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

p27Kip1 induces drug resistance by preventing apoptosis upstream of cytochrome c release and procaspase-3 activation in leukemic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1)

21 January 2018

1 reference

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Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

21 January 2018

1 reference

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

21 January 2018

1 reference

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Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

Peptidyl aldehyde inhibitors of proteasome induce apoptosis rapidly in mouse lymphoma RVC cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

p53-dependent induction of apoptosis by proteasome inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

Proteasomes play an essential role in thymocyte apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

Reentry into the cell cycle of contact-inhibited vascular endothelial cells by a phosphatase inhibitor. Possible involvement of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR–ABL tyrosine kinase, CGP 57148

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

p27Kip1 overexpression causes apoptotic death of mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

Treatment of Philadelphia leukemia in severe combined immunodeficient mice by combination of cyclophosphamide and bcr/abl antisense oligodeoxynucleotides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401159

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401159

1 reference

PubMed ID

12700629

Dimensions Publication ID

2 December 2017

0 references

1 reference

PubMed ID

12700629