Cardiostimulant and cardiodepressant effects through overexpressed human beta2-adrenoceptors in murine heart: regional differences and functional role of beta1-adrenoceptors. (Q44400235)

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scientific article published on 4 March 2003

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English	Cardiostimulant and cardiodepressant effects through overexpressed human beta2-adrenoceptors in murine heart: regional differences and functional role of beta1-adrenoceptors.	scientific article published on 4 March 2003

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12690430%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Cardiostimulant and cardiodepressant effects through overexpressed human beta2-adrenoceptors in murine heart: regional differences and functional role of beta1-adrenoceptors (English)

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2 November 2019

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Sian E. Harding

3

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2 November 2019

author name string

Jürgen F Heubach

1

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2 November 2019

Marianne Blaschke

2

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2 November 2019

Ursula Ravens

4

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2 November 2019

Alberto J Kaumann

5

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2 November 2019

publication date

4 March 2003

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2 November 2019

Naunyn-Schmiedeberg's Archives of Pharmacology

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2 November 2019

367

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2 November 2019

4

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2 November 2019

380-390

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2 November 2019

https://scigraph.springernature.com/pub.10.1007/s00210-002-0681-4

0 references

Activation of beta2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

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The affinity of (-)-propranolol for beta 1- and beta 2-adrenoceptors of human heart. Differential antagonism of the positive inotropic effects and adenylate cyclase stimulation by (-)-noradrenaline and (-)-adrenaline

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G(i)-dependent suppression of beta(1)-adrenoceptor effects in ventricular myocytes from NE-treated guinea pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta1-adrenergic receptors mediate beta3-adrenergic-independent effects of CGP 12177 in brown adipose tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell logic for dual coupling of a single class of receptors to G(s) and G(i) proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hyperpolarization-activated current If in ventricular myocytes of non-transgenic and beta2-adrenoceptor overexpressing mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-type calcium current and contractility in ventricular myocytes from mice overexpressing the cardiac beta 2-adrenoceptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pertussis toxin suppresses carbachol-evoked cardiodepression but does not modify cardiostimulation mediated through beta1- and putative beta4-adrenoceptors in mouse left atria: no evidence for beta2- and beta3-adrenoreceptor function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interspecies differences in the cardiac negative inotropic effects of beta(3)-adrenoceptor agonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Putative beta 4-adrenoceptors in rat ventricle mediate increases in contractile force and cell Ca2+: comparison with atrial receptors and relationship to (-)-[3H]-CGP 12177 binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both beta(2)- and beta(1)-adrenergic receptors mediate hastened relaxation and phosphorylation of phospholamban and troponin I in ventricular myocardium of Fallot infants, consistent with selective coupling of beta(2)-adrenergic receptors to G(s)-pr

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Convenient apparatus for recording contractions of isolated heart muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coexistence of functioning beta 1- and beta 2-adrenoceptors in single myocytes from human ventricle

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Negative inotropic effects of isoprenaline on isolated left atrial assays from aged transgenic mice with cardiac over-expression of human beta(2)-adrenoceptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta 2-adrenoceptor-mediated positive inotropic effect of adrenaline in human ventricular myocardium. Quantitative discrepancies with binding and adenylate cyclase stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Murine ventricular L-type Ca(2+) current is enhanced by zinterol via beta(1)-adrenoceptors, and is reduced in TG4 mice overexpressing the human beta(2)-adrenoceptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i).

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Action potential shortening through the putative beta4-adrenoceptor in ferret ventricle: comparison with beta1- and beta2-adrenoceptor-mediated effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of Gi-protein inactivation on basal, and beta(1)- and beta(2)AR-stimulated contraction of myocytes from transgenic mice overexpressing the beta(2)-adrenoceptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anomalous behavior of CGP 12177A on beta 1-adrenergic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of beta 1- and beta 2-adrenoceptors of human atrium and ventricle to the effects of noradrenaline and adrenaline as assessed with (-)-atenolol

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mediation of the positive chronotropic effect of CGP 12177 and cyanopindolol in the pithed rat by atypical beta-adrenoceptors, different from beta 3-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological antagonism between ventricular beta 1-adrenoceptors and alpha 1-adrenoceptors but no evidence for beta 2- and beta 3-adrenoceptor function in murine heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous beta(2)-adrenergic signaling fails to modulate L-type Ca(2+) current in mouse ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoprenaline can activate the acetylcholine-induced K+ current in canine atrial myocytes via Gs-derived betagamma subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of (-)-RO363 at human atrial beta-adrenoceptor subtypes, the human cloned beta 3-adrenoceptor and rodent intestinal beta 3-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective beta 1-adrenoceptor blockade enhances positive inotropic responses to endogenous catecholamines mediated through beta 2-adrenoceptors in human atrial myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of a low beta 1-adrenoceptor selectivity of [3H]CGP-12177 for resolving subtype-selectivity of competitive ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beta-adrenoceptor subtype(s) mediating adrenaline- and dobutamine-induced blood pressure and heart rate changes in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abolition of (-)-CGP 12177-evoked cardiostimulation in double beta1/beta2-adrenoceptor knockout mice. Obligatory role of beta1-adrenoceptors for putative beta4-adrenoceptor pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of the effects of adrenaline and noradrenaline on human heart: the role of beta 1- and beta 2-adrenoceptors in the stimulation of adenylate cyclase and contractile force

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00210-002-0681-4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12690430%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12690430%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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